{"id":"W2995096576","doi":"10.7554/elife.51163","title":"Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; Genome Canada; St. Jude Children's Research Hospital; Max-Planck-Gesellschaft; University of Nevada, Las Vegas","keywords":"Ubiquitin ligase; Ubiquitin; Cullin; Enzyme; Skp1; DNA ligase; Ubiquitin-Protein Ligases; Cell division control protein 4; Biology; Biochemistry; Cell biology; Ubiquitin-conjugating enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002555503,0.0001526875,0.0001669249,0.00004118221,0.00005587375,0.00002446991,0.0001340695,0.0001947213,0.0001511879],"category_scores_gemma":[0.00005845377,0.000154575,0.0001010266,0.0001019632,0.0000286253,0.0000121159,0.00009842089,0.0001072401,0.00006388292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001395986,"about_ca_system_score_gemma":0.00005176147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007792981,"about_ca_topic_score_gemma":0.00001015474,"domain_scores_codex":[0.9989218,0.00004839787,0.0002537596,0.0003477414,0.0002099336,0.0002184177],"domain_scores_gemma":[0.9992505,0.00001344369,0.0001514312,0.0003702273,0.0001283643,0.00008602489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275924,0.00007498333,0.01128228,0.00004586928,0.00002802504,3.022546e-7,0.0001084062,0.00006556341,0.9831639,0.00004649644,0.002391494,0.002665098],"study_design_scores_gemma":[0.000716227,0.0002986647,0.002484268,0.00002379537,0.00001372928,0.000001760339,0.00007186364,0.00092102,0.9793227,0.00002036475,0.01594589,0.0001797055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920846,0.001041868,0.004136236,0.00004881928,0.0001906096,0.0002948005,0.0001007726,0.00002681265,0.00207544],"genre_scores_gemma":[0.997667,0.00008822949,0.0006068128,0.0004877137,0.0001802709,0.00001868478,0.0002498257,0.00002417271,0.0006772873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01355439,"threshold_uncertainty_score":0.6303387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859583644995946,"score_gpt":0.2223004254742904,"score_spread":0.203704589024331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}