{"id":"W2995096576","doi":"10.7554/elife.51163","title":"Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; Genome Canada; St. Jude Children's Research Hospital; Max-Planck-Gesellschaft; University of Nevada, Las Vegas","keywords":"Ubiquitin ligase; Ubiquitin; Cullin; Enzyme; Skp1; DNA ligase; Ubiquitin-Protein Ligases; Cell division control protein 4; Biology; Biochemistry; Cell biology; Ubiquitin-conjugating enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361451,0.000627682,0.000516739,0.0004561252,0.0002623531,0.001411422,0.0003642477,0.00041996,0.001305718],"category_scores_gemma":[0.0002165389,0.0003030508,0.0004862633,0.0004018703,0.0003799492,0.0004986825,0.0008257236,0.0005545941,0.0006995718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005043388,"about_ca_system_score_gemma":0.0001895921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674486,"about_ca_topic_score_gemma":0.0003566732,"domain_scores_codex":[0.9994512,0.00004093813,0.00006171348,0.0002025179,0.0001431764,0.0001004002],"domain_scores_gemma":[0.9997484,0.00002072982,0.00007048114,0.00007191322,0.00002867289,0.00005978293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038278,0.0000123104,0.0008696254,0.00003796055,0.00002134051,0.0001070973,0.000007857396,0.0001077992,0.9958076,0.0002891037,0.00004900346,0.002586264],"study_design_scores_gemma":[0.000013018,0.0001050957,0.01603163,0.00001000195,0.0000370906,0.0007249152,0.00003029713,0.0007593558,0.976533,0.0002989119,0.005441388,0.00001520662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803207,0.00480004,0.01081087,0.0001411048,0.00003563954,0.00002424294,0.0007927903,0.0003673678,0.002707287],"genre_scores_gemma":[0.993796,0.001011932,0.002538338,0.00006079716,0.00001043699,0.00002086266,0.0006316159,0.00003411036,0.001895813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411422,"threshold_uncertainty_score":0.004368126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859583644995946,"score_gpt":0.2223004254742904,"score_spread":0.203704589024331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}