{"id":"W2995099757","doi":"10.1016/j.jval.2019.09.2178","title":"PNS278 A REVIEW OF HEALTH TECHNOLOGY ASSESSMENT GUIDELINES ON THE APPROVAL OF BIOSIMILARS","year":2019,"lang":"en","type":"review","venue":"Value in Health","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biosimilar; Medicine; Drug approval; Health technology; Pharmacology; Political science; Health care; Drug; Internal medicine; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01054577,0.0004845923,0.004952579,0.0005249525,0.00007852203,0.000003147462,0.00085934,0.001058634,0.0001799694],"category_scores_gemma":[0.00108915,0.0002701235,0.0006407113,0.001271621,0.0004013235,0.00001172284,0.0002173604,0.001790463,0.00002823126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002680241,"about_ca_system_score_gemma":0.002800298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002259833,"about_ca_topic_score_gemma":0.000003464546,"domain_scores_codex":[0.9902736,0.004369277,0.003938363,0.000632987,0.0001433387,0.0006424143],"domain_scores_gemma":[0.9945638,0.001177313,0.002835189,0.001204077,0.0001846825,0.00003497478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005554275,0.0001608997,0.000005505042,0.1977265,0.000173842,5.806625e-7,0.000007375671,8.808049e-7,0.00000235462,0.01384894,0.02134579,0.7667218],"study_design_scores_gemma":[0.0001609345,0.0007036725,0.00000271911,0.2038358,0.000120093,0.00002399231,0.00002729825,0.00000438355,0.00001027005,0.000197974,0.794755,0.0001578755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[8.361112e-7,0.948194,0.00005373809,0.04784663,0.0006632903,0.002730065,0.0002136405,0.00002359721,0.0002742128],"genre_scores_gemma":[0.000002585341,0.9870925,0.003439022,0.009096699,0.00002344105,0.00008772572,0.00005675049,0.00003651889,0.0001647651],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7734092,"threshold_uncertainty_score":0.9999751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3409310907795893,"score_gpt":0.4982831851940395,"score_spread":0.1573520944144501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}