{"id":"W2995136651","doi":"10.1126/sciimmunol.aax8189","title":"GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Immunosuppression; Tumor microenvironment; Macrophage; Function (biology); Immunology; Immune system; Microbiology; Cancer research; Biology; Cell biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009283044,0.0002388164,0.0001389055,0.0002307035,0.0001073104,0.0002329048,0.0001094653,0.0001753617,0.001553857],"category_scores_gemma":[0.00007608303,0.00008586954,0.0001242684,0.0001233172,0.0002485813,0.00007839841,0.0001418643,0.000506784,0.0002284548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086275,"about_ca_system_score_gemma":0.0001816125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008659909,"about_ca_topic_score_gemma":0.002523765,"domain_scores_codex":[0.9998664,0.00002467122,0.000006773809,0.00004004375,0.00003708534,0.00002503299],"domain_scores_gemma":[0.9999378,0.000009750964,0.00001557157,0.000009945257,0.000005562458,0.00002129599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007881986,0.00001657463,0.0003037512,0.00001423647,0.000003400366,0.0000295841,0.000007521183,0.00005041811,0.9984902,0.00008302939,0.00007354361,0.00084881],"study_design_scores_gemma":[0.00002725561,0.0001726088,0.009151938,0.000006721179,0.00001608505,0.0003790261,0.00004268465,0.002162671,0.9830957,0.00009148055,0.0048502,0.000003651354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940478,0.0008647442,0.002056081,0.0001626556,0.00004091006,0.00002144189,0.0007987168,0.000121062,0.001886653],"genre_scores_gemma":[0.9958187,0.0002198154,0.001058374,0.00004849595,0.000006257438,0.00002909184,0.0004716696,0.00002241732,0.002325181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553857,"threshold_uncertainty_score":0.005198181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003455892869424431,"score_gpt":0.2046016559611263,"score_spread":0.2011457630917019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}