{"id":"W2995187768","doi":"10.1002/iub.2211","title":"MicroRNAs and exosomes: Small molecules with big actions in multiple myeloma pathogenesis","year":2019,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Microvesicles; microRNA; Stromal cell; Multiple myeloma; Tumor microenvironment; Biology; Cancer research; Pathogenesis; Gene silencing; Cancer cell; Bone marrow; Cell biology; Cancer; Function (biology); Gene; Immunology; Tumor cells; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001181651,0.0004653627,0.0007526318,0.0001461025,0.00005570195,0.00004639395,0.0003144869,0.0004406681,0.000007822648],"category_scores_gemma":[0.0001536783,0.0003944681,0.0002305349,0.0001859881,0.0001190721,0.000003007273,0.0002079851,0.0002065838,0.0000442132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003260041,"about_ca_system_score_gemma":0.0004961957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001811852,"about_ca_topic_score_gemma":0.0001177259,"domain_scores_codex":[0.9982187,0.0001724895,0.0004037719,0.0007533684,0.0001031205,0.0003485953],"domain_scores_gemma":[0.9987405,0.00005290292,0.0002306606,0.0007474318,0.00004663962,0.000181887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009876733,0.0003127817,0.001178872,0.0128529,0.0005440853,0.0001385684,0.00004045626,0.00001840489,0.01733465,0.0000224167,0.0005338544,0.9669243],"study_design_scores_gemma":[0.0007456336,0.0001022277,0.0002963768,0.00188667,0.0004203024,0.00008452532,0.0000398797,0.00000476223,0.001061678,0.000002943985,0.9947351,0.0006199469],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01367293,0.9848035,0.0002158361,0.00001472467,0.0001470587,0.000724757,0.0002207066,0.00001816998,0.0001823305],"genre_scores_gemma":[0.002044349,0.9950588,0.00103653,0.00009154261,0.0002124479,0.0001846218,0.000526053,0.0001253139,0.000720305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942012,"threshold_uncertainty_score":0.9998507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06888746025998692,"score_gpt":0.2898518681204984,"score_spread":0.2209644078605115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}