{"id":"W2995187768","doi":"10.1002/iub.2211","title":"MicroRNAs and exosomes: Small molecules with big actions in multiple myeloma pathogenesis","year":2019,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Microvesicles; microRNA; Stromal cell; Multiple myeloma; Tumor microenvironment; Biology; Cancer research; Pathogenesis; Gene silencing; Cancer cell; Bone marrow; Cell biology; Cancer; Function (biology); Gene; Immunology; Tumor cells; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006146526,0.0008488755,0.001110134,0.001992138,0.0003141051,0.001071781,0.0007879937,0.001492117,0.002276012],"category_scores_gemma":[0.0007005896,0.0002622363,0.0003799372,0.001829854,0.000598983,0.001737183,0.0008503837,0.001833062,0.001676451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006592972,"about_ca_system_score_gemma":0.0008706428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004776095,"about_ca_topic_score_gemma":0.0008262061,"domain_scores_codex":[0.9998242,0.00003318511,0.00002499786,0.0000275377,0.00007123654,0.00001881475],"domain_scores_gemma":[0.9997039,0.000145481,0.00003591921,0.00001075329,0.00006390798,0.00004005725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007110015,0.00005776549,0.0001549383,0.007586906,0.00005396926,0.0002472546,0.00005698681,0.0002881072,0.002065139,0.005770927,0.0306324,0.9530145],"study_design_scores_gemma":[0.00001223775,0.00007073957,0.0005190698,0.001901753,0.00004496622,0.001223963,0.00004042429,0.00007382808,0.0005421424,0.002661602,0.9928945,0.00001469758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008136317,0.9986639,0.0001024328,0.0003033842,0.000268694,0.000002357721,0.000008185501,0.000006665626,0.0005630197],"genre_scores_gemma":[0.0005553818,0.9983089,0.0001500197,0.0002064362,0.0002335089,0.000005564774,0.00001884831,0.000001330697,0.0005199339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002276012,"threshold_uncertainty_score":0.007614017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06888746025998692,"score_gpt":0.2898518681204984,"score_spread":0.2209644078605115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}