{"id":"W2995292698","doi":"10.1002/path.5375","title":"p53 immunohistochemistry is an accurate surrogate for <i>TP53</i> mutational analysis in endometrial carcinoma biopsies","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Vancouver General Hospital","funders":"Cancer Research UK","keywords":"Immunohistochemistry; Biology; Amplicon; Serous carcinoma; Serous fluid; Concordance; Carcinoma; Pathology; Staining; Ovarian carcinoma; Polymerase chain reaction; Cancer; Medicine; Genetics; Gene; Ovarian cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007381815,0.0001125045,0.0002750189,0.0001563645,0.00003979166,0.00001491895,0.0002948368,0.00009943275,0.00003146658],"category_scores_gemma":[0.000209768,0.00008803421,0.0002013338,0.0002193625,0.00007586055,0.000006276757,0.00005532262,0.0001167061,0.000002514816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003178261,"about_ca_system_score_gemma":0.0001636425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000231148,"about_ca_topic_score_gemma":0.00003041075,"domain_scores_codex":[0.9990873,0.00009067408,0.0003962711,0.0001465926,0.00009666534,0.000182462],"domain_scores_gemma":[0.998961,0.0001720495,0.0003509926,0.0002641585,0.0002056284,0.00004614396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012165,0.00007377772,0.01394305,0.00001154984,0.0002057476,0.00003254979,0.0004419247,0.002835733,0.9805194,0.0000277194,0.0003398548,0.0003522094],"study_design_scores_gemma":[0.01646439,0.005005916,0.1060086,0.00003157962,0.001943483,0.002218399,0.00212683,0.001674352,0.8549356,0.002035692,0.006631137,0.0009240235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966997,0.001648957,0.0007894533,0.0001973161,0.0003284008,0.000129001,0.0001111229,0.00000110465,0.00009495711],"genre_scores_gemma":[0.998502,0.0003001002,0.0004244722,0.0003220305,0.0002636484,0.000004881395,0.00006100506,0.00001178301,0.0001100465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1255838,"threshold_uncertainty_score":0.3589931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413420258792055,"score_gpt":0.2856370096278998,"score_spread":0.2715028070399793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}