{"id":"W2995406279","doi":"10.1016/j.devcel.2019.11.005","title":"Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Joubert syndrome; Cilium; Cell biology; Ciliopathy; Neuroscience; Primary (astronomy); Signal transduction; Genetics; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001228246,0.0002484151,0.0002014845,0.00007524981,0.00006744087,0.00002812133,0.00014162,0.0001493957,0.0001426257],"category_scores_gemma":[0.000006255971,0.0002459966,0.00004929641,0.0001139869,0.00004773996,0.00001291843,0.0001460383,0.0001003708,0.00005241369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005314669,"about_ca_system_score_gemma":0.0003543785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001398996,"about_ca_topic_score_gemma":0.000009800101,"domain_scores_codex":[0.9985967,0.00003183102,0.0003433818,0.0004976518,0.000196083,0.0003343386],"domain_scores_gemma":[0.9996216,0.0000102663,0.00006555741,0.0001234657,0.0000215717,0.0001575306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002216704,0.001003036,0.1972541,0.0004337423,0.0001827667,0.00005160843,0.002820559,0.000273434,0.7907865,0.000007485025,0.0008804563,0.006084687],"study_design_scores_gemma":[0.004866831,0.0003532103,0.4118235,0.0002027546,0.00003941551,0.0001729755,0.001258814,0.0006043383,0.5667309,0.0004776251,0.01181746,0.001652271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931284,0.0008620126,0.0000604511,0.00004771747,0.0000689712,0.0004121239,0.00001756413,0.00001400574,0.005388793],"genre_scores_gemma":[0.9936506,0.0000780583,0.00381965,0.0002832576,0.000005838195,0.00003289133,0.0003948025,0.0000299147,0.001705011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2240556,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005299599455771646,"score_gpt":0.1852376138259353,"score_spread":0.1799380143701637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}