{"id":"W2995406730","doi":"10.1089/can.2019.0028","title":"Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent","year":2019,"lang":"en","type":"article","venue":"Cannabis and Cannabinoid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"GW Research; Greenwich Biosciences","keywords":"TRPV1; Cannabidiol; Knockout mouse; Epilepsy; Pharmacology; Dravet syndrome; Chemistry; Transient receptor potential channel; Wild type; Receptor; Medicine; Neuroscience; Biology; Biochemistry; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694473,0.0008780968,0.0008503842,0.0005280891,0.0001577485,0.0002639679,0.0003003886,0.0003206524,0.002708394],"category_scores_gemma":[0.0001680891,0.0001826851,0.0003720252,0.0002745355,0.0004108182,0.0002973098,0.0001888255,0.00106079,0.0005253482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004357244,"about_ca_system_score_gemma":0.0006687409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222025,"about_ca_topic_score_gemma":0.003436023,"domain_scores_codex":[0.9998223,0.00001936052,0.00001783174,0.00002618425,0.00006107624,0.00005328999],"domain_scores_gemma":[0.9998538,0.00001687366,0.00004608602,0.00002260071,0.00002220352,0.00003840813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002157542,0.0004730846,0.0002642905,0.0001404357,0.00002427683,0.000172705,0.00002648,0.00006666811,0.9902997,0.0000906975,0.0001600669,0.006123962],"study_design_scores_gemma":[0.0007337141,0.009651985,0.01065133,0.0000340443,0.0001154856,0.001142095,0.0000603356,0.0009824677,0.9737114,0.0001104724,0.002786611,0.00002011771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945742,0.001346986,0.001190083,0.0001454241,0.00005476867,0.0001237397,0.000515856,0.0001676359,0.001881281],"genre_scores_gemma":[0.9917189,0.001588068,0.001714739,0.0001062265,0.00002190521,0.0001861405,0.0006290901,0.00002288308,0.004012018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002708394,"threshold_uncertainty_score":0.009060502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350980338083131,"score_gpt":0.2986861908631304,"score_spread":0.2635881570548173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}