{"id":"W2995421271","doi":"10.1016/j.jval.2019.09.2328","title":"PPM11 TUMOUR-SPECIFIC RANDOMIZED CONTROLLED TRIALS IN RARE ONCOGENE-DRIVEN CANCERS: ASKING FOR THE IMPOSSIBLE?","year":2019,"lang":"en","type":"article","venue":"Value in Health","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada); Memorial University of Newfoundland","funders":"","keywords":"Medicine; Randomized controlled trial; Sample size determination; Clinical trial; Internal medicine; Oncology; Hazard ratio; Confidence interval; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008255329,0.0001926371,0.001779722,0.0001036219,0.00007037535,0.00004995937,0.0002345679,0.0001264022,0.00002386929],"category_scores_gemma":[0.002019414,0.0001301207,0.0004928957,0.0001245899,0.000047741,0.000003136848,0.00005480772,0.0001313464,0.000004289062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411302,"about_ca_system_score_gemma":0.001028709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002501845,"about_ca_topic_score_gemma":0.0009185036,"domain_scores_codex":[0.9967201,0.001005762,0.001340682,0.0003830528,0.0001348114,0.0004156457],"domain_scores_gemma":[0.9953579,0.003579846,0.0005750998,0.0003473078,0.00006333336,0.00007656528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3449199,0.0003336783,0.00783077,0.0006286502,0.0007905248,0.00001186876,0.001848356,0.5151611,0.09607035,0.00874689,0.01073513,0.01292279],"study_design_scores_gemma":[0.8650191,0.0008901221,0.0006560247,0.0006212246,0.0001057928,0.00001021582,0.0008013144,0.05378382,0.01055155,0.001950417,0.06492957,0.0006808718],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9116768,0.06795701,0.002549581,0.003273691,0.002097266,0.0117903,0.0001760882,0.00001187964,0.0004674418],"genre_scores_gemma":[0.975741,0.02099621,0.0007267101,0.0008740378,0.0006279098,0.000810016,0.00005867129,0.00003363391,0.0001317981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5200992,"threshold_uncertainty_score":0.5306169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023934404654731,"score_gpt":0.3192069739619339,"score_spread":0.2789676299153866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}