{"id":"W2995421271","doi":"10.1016/j.jval.2019.09.2328","title":"PPM11 TUMOUR-SPECIFIC RANDOMIZED CONTROLLED TRIALS IN RARE ONCOGENE-DRIVEN CANCERS: ASKING FOR THE IMPOSSIBLE?","year":2019,"lang":"en","type":"article","venue":"Value in Health","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada); Memorial University of Newfoundland","funders":"","keywords":"Medicine; Randomized controlled trial; Sample size determination; Clinical trial; Internal medicine; Oncology; Hazard ratio; Confidence interval; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.07708823,0.0009938058,0.007025158,0.0005436924,0.000706882,0.004057761,0.001878213,0.005753546,0.007422644],"category_scores_gemma":[0.1202214,0.0007083612,0.006732393,0.001276537,0.004513521,0.005887038,0.00158553,0.00876159,0.0009929285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00221525,"about_ca_system_score_gemma":0.00354884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001450666,"about_ca_topic_score_gemma":0.003149985,"domain_scores_codex":[0.933118,0.05763728,0.004047688,0.002103577,0.001975938,0.001117508],"domain_scores_gemma":[0.8445779,0.1335717,0.01009203,0.005572403,0.003441073,0.00274484],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.3655891,0.001318613,0.007994672,0.05752067,0.07261451,0.0003132692,0.001143765,0.003978747,0.002398445,0.05410852,0.06881963,0.3642001],"study_design_scores_gemma":[0.5417663,0.03247696,0.01665687,0.04317179,0.04685876,0.0004098165,0.001354947,0.005887063,0.001670132,0.1524778,0.1568608,0.0004088088],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.09553459,0.4441662,0.03543929,0.3704528,0.03090485,0.004781959,0.003075986,0.0005671084,0.01507725],"genre_scores_gemma":[0.7221814,0.07019351,0.04077435,0.1373817,0.01499399,0.009137297,0.001237104,0.000226751,0.003873869],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9229118,"threshold_uncertainty_score":0.4076864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023934404654731,"score_gpt":0.3192069739619339,"score_spread":0.2789676299153866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}