{"id":"W2995430119","doi":"10.1038/s41467-019-13538-y","title":"Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Wellcome Trust; Agence Nationale de la Recherche; Université de Paris; European Commission; King's College London; Crohn's and Colitis Foundation; National Institute for Health and Care Research; Kenneth Rainin Foundation; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Flagellin; Inflammation; Immunology; Gut flora; Immunity; Microbiology; Biology; Inflammatory bowel disease; Feces; Colitis; Bacteria; Immune system; Medicine; Disease; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705184,0.0003718953,0.0002966518,0.0002253237,0.00009581308,0.0002163478,0.0002224013,0.0004235525,0.0009964178],"category_scores_gemma":[0.0001713722,0.0001204113,0.0002244975,0.00007899855,0.0002988447,0.0001605971,0.0002121443,0.0008966453,0.0002301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961447,"about_ca_system_score_gemma":0.0002024822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001962949,"about_ca_topic_score_gemma":0.0003667266,"domain_scores_codex":[0.9998285,0.00004385013,0.00001081754,0.00002480708,0.00002939871,0.00006256879],"domain_scores_gemma":[0.9998462,0.00002157637,0.00004489338,0.00001972998,0.00001309875,0.00005439667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010998,0.0002162927,0.0002991208,0.0000586571,0.000009319482,0.00003104977,0.00001475785,0.00008160424,0.9941239,0.00009629791,0.00005722268,0.004000792],"study_design_scores_gemma":[0.0006456816,0.01078015,0.0159714,0.00004395054,0.00005279254,0.0004216628,0.00006006583,0.002369483,0.9644372,0.0001974327,0.005008924,0.00001131379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965231,0.001102295,0.001182522,0.000194677,0.00006597038,0.00003481729,0.00008632399,0.00007572851,0.0007345801],"genre_scores_gemma":[0.9969791,0.000506598,0.001020905,0.0001174128,0.00004018336,0.00002695253,0.0001552217,0.00001268832,0.001140978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009964178,"threshold_uncertainty_score":0.00333333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006051203789712122,"score_gpt":0.2539616436724972,"score_spread":0.247910439882785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}