{"id":"W2995462641","doi":"10.1097/pas.0000000000001422","title":"“Renal Cell Carcinoma With Leiomyomatous Stroma” Harbor Somatic Mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): Clinicopathologic and Molecular Characterization of 18 Sporadic Tumors Supports a Distinct Entity","year":2019,"lang":"en","type":"article","venue":"The American Journal of Surgical Pathology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tuberous sclerosis; Renal cell carcinoma; Pathology; Biology; Stroma; TSC1; Carcinoma; Immunohistochemistry; Clear cell; Clear cell carcinoma; Cancer research; Medicine; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003897844,0.0002407656,0.0002222684,0.0008059343,0.0003682677,0.0003240312,0.000267859,0.0002021553,0.000608391],"category_scores_gemma":[0.0008020832,0.0001616907,0.0001866958,0.00041219,0.0005487603,0.0002105008,0.000310453,0.0001328338,0.0001660665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002643122,"about_ca_system_score_gemma":0.0003156532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139449,"about_ca_topic_score_gemma":0.00210438,"domain_scores_codex":[0.999751,0.00003195183,0.00003388998,0.00007493802,0.0000526687,0.00005559115],"domain_scores_gemma":[0.9995522,0.00009628902,0.0001476655,0.00005737711,0.00005649683,0.00009003817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003331169,0.00005232891,0.9619806,0.00003983913,0.00003507659,0.00894584,0.0003159276,0.00008529479,0.0234188,0.0000810302,0.00009315852,0.004619025],"study_design_scores_gemma":[0.000036797,0.0003574312,0.9002015,0.00001184332,0.00008392319,0.0856144,0.0004831218,0.001183024,0.01082569,0.00009920363,0.001091185,0.00001194738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999617,0.0000916686,0.0001193695,0.000004586989,8.081882e-7,0.000004945591,0.00001896338,0.00000380149,0.0001388091],"genre_scores_gemma":[0.9996351,0.00003410262,0.0002000934,0.000005312847,0.000004022225,0.000002898208,0.00008652241,9.61454e-7,0.00003093719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139449,"threshold_uncertainty_score":0.002265632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101238813729447,"score_gpt":0.2474802413866812,"score_spread":0.2364678532493868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}