{"id":"W2995462641","doi":"10.1097/pas.0000000000001422","title":"“Renal Cell Carcinoma With Leiomyomatous Stroma” Harbor Somatic Mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): Clinicopathologic and Molecular Characterization of 18 Sporadic Tumors Supports a Distinct Entity","year":2019,"lang":"en","type":"article","venue":"The American Journal of Surgical Pathology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tuberous sclerosis; Renal cell carcinoma; Pathology; Biology; Stroma; TSC1; Carcinoma; Immunohistochemistry; Clear cell; Clear cell carcinoma; Cancer research; Medicine; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005704613,0.0002366419,0.001195821,0.000213959,0.00004243321,0.000009485949,0.0001294118,0.00005381274,0.0001349476],"category_scores_gemma":[0.00003989239,0.0001322964,0.0001444268,0.0002629901,0.001080197,0.00007762679,0.00006074557,0.0002698144,0.000003013273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003852281,"about_ca_system_score_gemma":0.0002183414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001890487,"about_ca_topic_score_gemma":9.118689e-7,"domain_scores_codex":[0.9978089,0.0004172905,0.0009087687,0.0002519674,0.0003549382,0.0002581096],"domain_scores_gemma":[0.9972618,0.0002880855,0.0017531,0.0003177736,0.0001828623,0.0001964174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00401059,0.0006812196,0.7087911,0.0002729253,0.0001077637,0.01469511,0.0006273756,0.000009473313,0.2691843,0.00004743252,0.000003337387,0.001569411],"study_design_scores_gemma":[0.003431786,0.01128494,0.9504796,0.0001321083,0.0005419642,0.01983283,0.0004474787,0.00006308545,0.01358178,0.00004655926,0.0000149644,0.0001429139],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987274,0.0002704378,0.0001821241,0.0002330121,0.00004519776,0.0004106202,0.00003176164,0.000008635744,0.00009075853],"genre_scores_gemma":[0.998877,0.00008462289,0.000867155,0.00005105282,0.00003341605,0.000006763077,0.00002365288,0.00002588508,0.00003048113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2556025,"threshold_uncertainty_score":0.5394892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101238813729447,"score_gpt":0.2474802413866812,"score_spread":0.2364678532493868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}