{"id":"W2995562313","doi":"10.1186/s13063-019-3766-9","title":"A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial","year":2019,"lang":"en","type":"article","venue":"Trials","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Newcastle University; University of Southampton; National Institute for Health and Care Research; Queen's University Belfast; Imperial College London; Queen's University; London School of Economics and Political Science; University of Dundee","keywords":"Medicine; Hypertonic saline; Sputum; Randomized controlled trial; Clinical trial; Intensive care medicine; Cost effectiveness; Anesthesia; Internal medicine; Tuberculosis; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01709032,0.006426586,0.008949823,0.001609434,0.001787046,0.002586,0.003246399,0.008547619,0.02882097],"category_scores_gemma":[0.01734695,0.002442663,0.00615038,0.001061184,0.004261087,0.003721008,0.001792056,0.00514653,0.004166509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002531624,"about_ca_system_score_gemma":0.005122122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185631,"about_ca_topic_score_gemma":0.001731447,"domain_scores_codex":[0.9882662,0.007829807,0.0007838518,0.001058816,0.0007841337,0.001277215],"domain_scores_gemma":[0.9905647,0.003480292,0.002276798,0.0009223163,0.001002778,0.001753184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9860237,0.008390944,0.0001854254,0.0008121362,0.0004134731,0.00004561185,0.00004760269,0.0003495234,0.0006588461,0.0002041392,0.0006486994,0.002219914],"study_design_scores_gemma":[0.9677049,0.0307616,0.0002769293,0.00005222895,0.0001709798,0.00001072118,0.00001134086,0.0002551834,0.00009701339,0.0001778827,0.0004685576,0.00001262338],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2513112,0.002488155,0.003263786,0.002137473,0.002275817,0.7300742,0.003844018,0.0002918041,0.004313517],"genre_scores_gemma":[0.183649,0.001042045,0.007048043,0.001986483,0.0008892024,0.7992237,0.001320502,0.00002884191,0.00481226],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02882097,"threshold_uncertainty_score":0.0964157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2766575852834015,"score_gpt":0.5392085206288374,"score_spread":0.2625509353454359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}