{"id":"W2995590943","doi":"10.1093/ijnp/pyz066","title":"Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report","year":2019,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Centre for Addiction and Mental Health; University of Toronto; University Health Network; Providence Health Care; McMaster University; St. Joseph’s Healthcare Hamilton; University of British Columbia; University of Calgary; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; H. Lundbeck A/S; Pfizer; Servier; Ontario Brain Institute; Government of Ontario; Bristol-Myers Squibb","keywords":"Escitalopram; Major depressive disorder; microRNA; Pharmacology; Association (psychology); Reuptake inhibitor; Serotonin Uptake Inhibitors; Serotonin reuptake inhibitor; Medicine; Citalopram; Serotonin; Oncology; Depression (economics); Internal medicine; Bioinformatics; Psychiatry; Psychology; Biology; Antidepressant; Genetics; Gene; Psychotherapist; Receptor; Hippocampus; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616195,0.000255517,0.000441275,0.0002297194,0.00005971644,0.00003426976,0.0001832427,0.000130305,0.00001684304],"category_scores_gemma":[0.0001885732,0.0001518102,0.00005975648,0.0001472841,0.00005310805,0.0001832781,0.00008837941,0.000554285,0.000001479032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182072,"about_ca_system_score_gemma":0.00008345229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003419337,"about_ca_topic_score_gemma":0.000007998796,"domain_scores_codex":[0.9981184,0.0003068007,0.0005118525,0.0003339683,0.0004971766,0.0002317717],"domain_scores_gemma":[0.9977642,0.0005975832,0.0009318439,0.0001307369,0.0004523841,0.0001232366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001913336,0.000324902,0.6078868,0.00001272669,0.0006078959,0.0002801459,0.0002907457,0.000003928465,0.3878121,2.265551e-7,0.0002486505,0.0006185523],"study_design_scores_gemma":[0.02230619,0.001414551,0.8353353,0.0002240585,0.0002993178,0.0003550604,0.00002359365,0.00001058161,0.1397611,0.00003581821,0.0001173033,0.0001171261],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965198,0.0003347223,0.000007235336,0.001616683,0.0003755014,0.0009937227,0.00007213226,0.00001686141,0.0000633289],"genre_scores_gemma":[0.9991401,0.00004835576,0.00007016116,0.0003679352,0.0001194438,0.00002643462,0.00003982566,0.00003673826,0.0001510192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.248051,"threshold_uncertainty_score":0.6190639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006336902332613565,"score_gpt":0.2482546514930891,"score_spread":0.2419177491604755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}