{"id":"W2995590943","doi":"10.1093/ijnp/pyz066","title":"Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report","year":2019,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Centre for Addiction and Mental Health; University of Toronto; University Health Network; Providence Health Care; McMaster University; St. Joseph’s Healthcare Hamilton; University of British Columbia; University of Calgary; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; H. Lundbeck A/S; Pfizer; Servier; Ontario Brain Institute; Government of Ontario; Bristol-Myers Squibb","keywords":"Escitalopram; Major depressive disorder; microRNA; Pharmacology; Association (psychology); Reuptake inhibitor; Serotonin Uptake Inhibitors; Serotonin reuptake inhibitor; Medicine; Citalopram; Serotonin; Oncology; Depression (economics); Internal medicine; Bioinformatics; Psychiatry; Psychology; Biology; Antidepressant; Genetics; Gene; Psychotherapist; Receptor; Hippocampus; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805155,0.0002020851,0.0003363573,0.0002870316,0.0002237161,0.0003064253,0.0001088504,0.000233982,0.0008664606],"category_scores_gemma":[0.0006659051,0.0001515006,0.0002951822,0.0003377406,0.00008938785,0.0001168587,0.0001831028,0.0002601721,0.000107564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234051,"about_ca_system_score_gemma":0.0001028113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278764,"about_ca_topic_score_gemma":0.003005241,"domain_scores_codex":[0.9998368,0.00002958089,0.00002228853,0.00004800756,0.00004140231,0.00002193114],"domain_scores_gemma":[0.999632,0.00005664755,0.0001900365,0.00001849269,0.00004271148,0.00006009496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005982555,0.0000403044,0.995357,0.0000169239,0.00009727807,0.0001048432,0.00003280802,0.00002954619,0.00155769,0.00000509291,0.00007416245,0.002086105],"study_design_scores_gemma":[0.0000109954,0.0001227276,0.9993761,0.000002173898,0.00003582931,0.0001988059,0.00002109517,0.00008630948,0.00008842799,0.000004231154,0.00005147919,0.000001915683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999424,0.0002219616,0.00003482782,0.0000140149,0.000003026374,0.000004880229,0.0001563031,0.000001513286,0.0001396202],"genre_scores_gemma":[0.9993217,0.00009867771,0.00006164879,0.00002692804,0.000007313462,0.000007151926,0.0003076014,9.621541e-7,0.000168132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001278764,"threshold_uncertainty_score":0.002898633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006336902332613565,"score_gpt":0.2482546514930891,"score_spread":0.2419177491604755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}