{"id":"W2995611313","doi":"10.1016/j.trci.2019.11.002","title":"Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Agentschap Innoveren en Ondernemen; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; National Institute of Neurological Disorders and Stroke; IXICO; Takeda Pharmaceutical Company; AbbVie; Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Merck; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Neurogranin; Neurodegeneration; Cognition; Disease; Internal medicine; Cognitive decline; Oncology; Neuroscience; Cohort; Medicine; Biomarker; Psychology; Dementia; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001459945,0.001057276,0.0005982407,0.001518142,0.0002929008,0.0009707886,0.0003097429,0.0005677054,0.001544441],"category_scores_gemma":[0.004614589,0.0002963216,0.0002305845,0.0007334477,0.0003180614,0.0005394444,0.0005035918,0.0004311017,0.0003857583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622348,"about_ca_system_score_gemma":0.0003432579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00144555,"about_ca_topic_score_gemma":0.002413789,"domain_scores_codex":[0.999649,0.00009132321,0.00005382672,0.0000734668,0.00009410995,0.00003820345],"domain_scores_gemma":[0.9987413,0.0003208009,0.0004703352,0.00007004968,0.000279068,0.0001185099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001236432,0.000156748,0.9611138,0.0001145852,0.0002893532,0.0002008276,0.00008187306,0.0002335641,0.00501858,0.00004472919,0.0009252636,0.03058423],"study_design_scores_gemma":[0.00006998014,0.0005392017,0.9923409,0.00009414559,0.0002135904,0.001296418,0.0001698183,0.0008481507,0.003087672,0.0004617875,0.0008613478,0.0000169425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901715,0.006706419,0.0006802476,0.0002354404,0.00006951633,0.00003898311,0.0007110435,0.00004998209,0.001336935],"genre_scores_gemma":[0.9964473,0.000992454,0.001385484,0.00009988923,0.00008183694,0.00002572519,0.0005243323,0.000005822785,0.0004372394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544441,"threshold_uncertainty_score":0.007721007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1280136971180143,"score_gpt":0.4678056458831709,"score_spread":0.3397919487651566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}