{"id":"W2995624998","doi":"10.7554/elife.45120","title":"Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis","year":2019,"lang":"en","type":"letter","venue":"eLife","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Centro Nacional de Investigaciones Cardiovasculares; Laura and John Arnold Foundation; McGill University","keywords":"Tumor microenvironment; Metastasis; Caveolin 1; Stromal cell; Biology; Replication (statistics); Cell biology; Cancer research; Cancer; Tumor cells; Virology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.006588495,0.0011872,0.001016195,0.000542278,0.0009364318,0.0007916571,0.001217712,0.001534946,0.004550041],"category_scores_gemma":[0.004889756,0.0005328252,0.002229149,0.0003223578,0.00108419,0.0006669171,0.001124581,0.002706721,0.001507141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007493579,"about_ca_system_score_gemma":0.001296298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001866555,"about_ca_topic_score_gemma":0.001361695,"domain_scores_codex":[0.9960019,0.001114857,0.0005162852,0.0009499166,0.0009972939,0.0004198097],"domain_scores_gemma":[0.991648,0.001769391,0.0008860276,0.003277307,0.001630152,0.0007891736],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002389908,0.001762571,0.004291783,0.0004909796,0.0001921585,0.0003930152,0.0003933429,0.0003175273,0.9766983,0.0006699267,0.004834029,0.007566487],"study_design_scores_gemma":[0.0007430134,0.0131294,0.01082036,0.0000488512,0.0003916642,0.001420155,0.0001652028,0.001635641,0.9548907,0.0004328399,0.01622216,0.0001000054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341776,0.003519155,0.04414828,0.002963841,0.002535966,0.002459298,0.004019478,0.001083834,0.00509247],"genre_scores_gemma":[0.9424291,0.0014683,0.03223731,0.002025491,0.0007938072,0.003955514,0.00457784,0.0007442866,0.01176823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9934115,"threshold_uncertainty_score":0.03484368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368163027246398,"score_gpt":0.2363483368182132,"score_spread":0.2226667065457492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}