{"id":"W2995628793","doi":"10.1124/pr.118.016311","title":"Imidazoline Receptor System: The Past, the Present, and the Future","year":2019,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Agmatine; Moxonidine; Rilmenidine; Clonidine; Receptor; Agonist; Chemistry; Pharmacology; Allosteric regulation; Stereochemistry; Biochemistry; Endocrinology; Medicine; Amino acid; Arginine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004493831,0.0009248622,0.001333307,0.001287433,0.0002363286,0.001086811,0.001111016,0.0009805528,0.003814034],"category_scores_gemma":[0.0004447263,0.0002147921,0.0003055394,0.001654566,0.0005084237,0.00144144,0.0004985442,0.001762969,0.002378184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006063866,"about_ca_system_score_gemma":0.0009355222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077577,"about_ca_topic_score_gemma":0.00289221,"domain_scores_codex":[0.999887,0.00002154208,0.00001531517,0.00002507383,0.00003487793,0.00001622431],"domain_scores_gemma":[0.9998235,0.00007139039,0.0000326464,0.000005391623,0.00004006243,0.00002707339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001832416,0.00008043885,0.0001308768,0.01283098,0.00005927773,0.0002481484,0.00004447626,0.0003175261,0.004252963,0.004882349,0.03833964,0.93863],"study_design_scores_gemma":[0.00003776526,0.000136999,0.0007322698,0.002564671,0.0001299311,0.001207019,0.00008306714,0.0001410957,0.0005213493,0.002818592,0.9916025,0.00002466298],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005795786,0.9990366,0.00008119521,0.0001957785,0.000166353,0.000001348813,0.000008342116,0.000005298083,0.0004472447],"genre_scores_gemma":[0.0004289167,0.9986095,0.0001492461,0.000154936,0.0002045953,0.000002689824,0.00001336149,8.653071e-7,0.0004357292],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003814034,"threshold_uncertainty_score":0.01275927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05844273434299099,"score_gpt":0.3711513324988874,"score_spread":0.3127085981558965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}