{"id":"W2995628793","doi":"10.1124/pr.118.016311","title":"Imidazoline Receptor System: The Past, the Present, and the Future","year":2019,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Agmatine; Moxonidine; Rilmenidine; Clonidine; Receptor; Agonist; Chemistry; Pharmacology; Allosteric regulation; Stereochemistry; Biochemistry; Endocrinology; Medicine; Amino acid; Arginine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003856855,0.0008024813,0.002062484,0.00002324474,0.0004709165,0.0001239684,0.001705185,0.0005373425,0.0003311297],"category_scores_gemma":[0.0002050375,0.0002387863,0.001295146,0.0002867139,0.000498807,0.000005479583,0.001043109,0.00118439,0.000456908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004901695,"about_ca_system_score_gemma":0.00008660459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002471959,"about_ca_topic_score_gemma":5.971735e-7,"domain_scores_codex":[0.9926476,0.00462879,0.0009424803,0.0008584167,0.0003025889,0.0006201041],"domain_scores_gemma":[0.9973592,0.0008512328,0.0007729576,0.0007536171,0.00006798479,0.0001949812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001116663,0.00004983337,2.957985e-7,0.005050152,0.0003358013,0.000003082472,0.00000861796,0.000001073939,0.0003658307,0.000647435,0.1924089,0.8010173],"study_design_scores_gemma":[0.0007258246,0.0001418794,5.998274e-7,0.0007031905,0.00230634,0.00006317012,0.00001722332,0.00002608521,0.00004909524,0.00001800042,0.9956069,0.0003417024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002444754,0.9871666,0.00005911184,0.002180782,0.002135212,0.007610019,0.00005257826,0.00003125597,0.0007400351],"genre_scores_gemma":[0.00005672465,0.984863,0.0000369509,0.002306927,0.00873065,0.002886109,0.0001121798,0.00004978121,0.0009577191],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.803198,"threshold_uncertainty_score":0.9737422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05844273434299099,"score_gpt":0.3711513324988874,"score_spread":0.3127085981558965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}