{"id":"W2995649728","doi":"10.1021/acsomega.9b03248","title":"Radiometal-Containing Aryl Diazonium Salts for Chemoselective Bioconjugation of Tyrosine Residues","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioconjugation; Chemistry; Tyrosine; Diazonium Compounds; Amino acid; Aryl; Combinatorial chemistry; Diazo; Electrophile; Salt (chemistry); Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049177,0.0001051608,0.000336663,0.0002549766,0.00003593138,0.000009401765,0.00004574607,0.00007109351,0.00004318827],"category_scores_gemma":[0.0001658008,0.00009316215,0.000135828,0.00044336,0.00003960263,0.0001133957,0.00001466668,0.00007750298,0.00003515549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005676809,"about_ca_system_score_gemma":0.00006562565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003352315,"about_ca_topic_score_gemma":0.000008591263,"domain_scores_codex":[0.9991891,0.00001200564,0.0002530381,0.0002072394,0.0001685438,0.0001701029],"domain_scores_gemma":[0.9992678,0.000104422,0.0001410191,0.0002002342,0.0002221882,0.00006439466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004905346,0.0001337646,0.02064666,0.0001833111,0.000202321,0.000002616403,0.0003463665,0.000005552166,0.9741625,0.001015683,0.001185258,0.001625391],"study_design_scores_gemma":[0.002805104,0.0006103229,0.02522994,0.0003064742,0.0001358798,0.000009255542,0.000262641,0.0002746408,0.9686608,0.0003669778,0.001206128,0.0001318176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959511,0.0001512555,0.0002922706,0.00089363,0.00003290706,0.000407136,0.00002191874,0.00004230774,0.002207512],"genre_scores_gemma":[0.9968231,0.000015963,0.0005627486,0.0004075739,0.0001177163,0.00002914564,0.000175918,0.00001798802,0.001849843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005501721,"threshold_uncertainty_score":0.3799042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445870387471703,"score_gpt":0.2781786047294917,"score_spread":0.2637199008547746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}