{"id":"W2995651451","doi":"10.1038/s41467-019-13392-y","title":"Functional significance of U2AF1 S34F mutations in lung adenocarcinomas","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"U.S. National Library of Medicine; U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; Ludwig Institute for Cancer Research; Howard Hughes Medical Institute","keywords":"RNA splicing; Exon; Alternative splicing; Transcriptome; Mutant; Biology; Spliceosome; Genetics; Intron; Mutation; RNA; Gene; Cancer research; Cell biology; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001523326,0.00006002597,0.00008008692,0.00007424908,0.00005502713,0.000007598395,0.0004436346,0.0001518209,0.00003415973],"category_scores_gemma":[0.0001207669,0.00006096656,0.00004653576,0.0002017714,0.00007734088,0.000005286833,0.0001629469,0.0003574244,0.00001485418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001976766,"about_ca_system_score_gemma":0.0001173582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004597836,"about_ca_topic_score_gemma":0.0004060432,"domain_scores_codex":[0.9993988,0.0000806282,0.000150491,0.0001359936,0.0001127558,0.0001213776],"domain_scores_gemma":[0.9988154,0.00006684728,0.00005140322,0.0009060131,0.0001258367,0.00003453261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002943833,0.00008684058,0.1705179,0.00001718096,0.00002380541,2.03407e-7,0.00003876078,0.0002266271,0.8218557,0.004419911,0.002488981,0.0002946799],"study_design_scores_gemma":[0.001249216,0.0001578805,0.8801944,0.00005174195,0.00001729973,0.00000915339,0.0004449155,0.004932497,0.08182844,0.0002705584,0.03055631,0.0002876004],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875501,0.006065962,0.0001849673,0.001025441,0.00005722157,0.0002628183,0.00002277239,0.00000599594,0.004824668],"genre_scores_gemma":[0.9965817,0.0002200709,0.001200455,0.0001043953,0.00002246693,0.00003676529,0.0003101135,0.000008313828,0.001515701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7400272,"threshold_uncertainty_score":0.2486144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653064428065958,"score_gpt":0.3028361712248866,"score_spread":0.286305526944227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}