{"id":"W2995694266","doi":"10.1111/jvh.13223","title":"Liver safety assessment in clinical trials of new agents for chronic hepatitis B","year":2019,"lang":"en","type":"review","venue":"Journal of Viral Hepatitis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); Toronto Liver Centre; University Health Network","funders":"Janssen Pharmaceuticals; Gilead Sciences; Novartis; GlaxoSmithKline","keywords":"Medicine; Clinical trial; Chronic hepatitis; Internal medicine; Intensive care medicine; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009019068,0.0006692621,0.01199537,0.0007582984,0.00005442354,0.00002868556,0.0004575825,0.0007478793,0.000646274],"category_scores_gemma":[0.005005206,0.0005014506,0.004582865,0.0003772452,0.0001374387,0.000238778,0.0001802198,0.001564289,0.00005681062],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001886032,"about_ca_system_score_gemma":0.006652599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004553291,"about_ca_topic_score_gemma":0.005283124,"domain_scores_codex":[0.9859098,0.001771398,0.01026901,0.0004788957,0.001013008,0.0005578758],"domain_scores_gemma":[0.9874417,0.003332468,0.007690677,0.0005692404,0.0005865804,0.0003793707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000177843,0.0003559008,0.04260547,0.01919374,0.001749991,0.0002807874,0.00006652741,0.000001479631,5.770774e-7,0.0001115916,0.024827,0.9106291],"study_design_scores_gemma":[0.004760138,0.004861522,0.0377212,0.05185664,0.005020022,0.0001624615,0.000002731856,0.0000718135,0.000001906778,0.00006758865,0.8951052,0.0003687307],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005654735,0.990989,0.0008773295,0.0001676337,0.00283035,0.003518787,0.0006082742,0.00001152449,0.0004316859],"genre_scores_gemma":[0.0005227389,0.9898205,0.004925163,0.000145458,0.002798004,0.00004916121,0.0001086906,0.0001169835,0.001513258],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9102604,"threshold_uncertainty_score":0.9997437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2887292913499422,"score_gpt":0.5224618920925622,"score_spread":0.23373260074262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}