{"id":"W2995708334","doi":"10.1158/1055-9965.epi-19-0755","title":"Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; Health and Medical Research Fund; National Center for Advancing Translational Sciences; National Research Foundation of Korea; Medical Research Council; National Health and Medical Research Council; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Chonnam National University Hwasun Hospital; Instituto de Salud Carlos III; Xunta de Galicia; Xarxa de Bancs de Tumors de Catalunya; National Institutes of Health; Junta de Castilla y León; Cancer Research UK; KWF Kankerbestrijding; National Natural Science Foundation of China; Vetenskapsrådet; Ministry of Education, Culture, Sports, Science and Technology; Federación Española de Enfermedades Raras; National Cancer Center; Ministerstvo Zdravotnictví Ceské Republiky; National Institute on Aging; National Institute for Health and Care Research; National Institute of Environmental Health Sciences; Fundación Científica Asociación Española Contra el Cáncer; Grantová Agentura České Republiky; Ministerio de Economía y Competitividad; Vanderbilt-Ingram Cancer Center","keywords":"Genome-wide association study; Linkage disequilibrium; Colorectal cancer; Genetics; Allele; Genetic association; Oncology; Indel; Biology; Internal medicine; Medicine; Single-nucleotide polymorphism; Cancer; Gene; Haplotype; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007208713,0.0004841342,0.0004054114,0.0007982571,0.0003789571,0.0005857171,0.0003767429,0.0003713417,0.003460499],"category_scores_gemma":[0.001301434,0.0001987204,0.0008156915,0.001288643,0.0003580927,0.000189254,0.0004173227,0.0004242983,0.0004096436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196226,"about_ca_system_score_gemma":0.0003155539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003237914,"about_ca_topic_score_gemma":0.003466738,"domain_scores_codex":[0.9997128,0.00005363256,0.00004986809,0.00009716427,0.00004902169,0.00003766231],"domain_scores_gemma":[0.9987726,0.0003395529,0.0003995718,0.000191968,0.0001448886,0.0001514009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001555653,0.000129001,0.9317595,0.0002373789,0.001139053,0.003790216,0.0006000412,0.0004318148,0.04467858,0.0004362914,0.0004423487,0.0148002],"study_design_scores_gemma":[0.00009638489,0.0001737879,0.9883306,0.00004134893,0.0007804284,0.003205021,0.0002401216,0.0009656209,0.004563611,0.0003446396,0.001238837,0.00001960302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972493,0.0005757569,0.001216253,0.00006181723,0.00001537725,0.00001305777,0.000336265,0.00002959795,0.0005025741],"genre_scores_gemma":[0.9979931,0.0002032235,0.001066237,0.00005024406,0.00002303809,0.000009844164,0.0003615623,0.00001083579,0.0002819451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003460499,"threshold_uncertainty_score":0.01157653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538365111797392,"score_gpt":0.3241952577189317,"score_spread":0.2988116066009578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}