{"id":"W2995708334","doi":"10.1158/1055-9965.epi-19-0755","title":"Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; Health and Medical Research Fund; National Center for Advancing Translational Sciences; National Research Foundation of Korea; Medical Research Council; National Health and Medical Research Council; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Chonnam National University Hwasun Hospital; Instituto de Salud Carlos III; Xunta de Galicia; Xarxa de Bancs de Tumors de Catalunya; National Institutes of Health; Junta de Castilla y León; Cancer Research UK; KWF Kankerbestrijding; National Natural Science Foundation of China; Vetenskapsrådet; Ministry of Education, Culture, Sports, Science and Technology; Federación Española de Enfermedades Raras; National Cancer Center; Ministerstvo Zdravotnictví Ceské Republiky; National Institute on Aging; National Institute for Health and Care Research; National Institute of Environmental Health Sciences; Fundación Científica Asociación Española Contra el Cáncer; Grantová Agentura České Republiky; Ministerio de Economía y Competitividad; Vanderbilt-Ingram Cancer Center","keywords":"Genome-wide association study; Linkage disequilibrium; Colorectal cancer; Genetics; Allele; Genetic association; Oncology; Indel; Biology; Internal medicine; Medicine; Single-nucleotide polymorphism; Cancer; Gene; Haplotype; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003094452,0.0002016712,0.0005390034,0.0001426766,0.00005200001,0.000004081098,0.0001572019,0.0004913314,0.00003261217],"category_scores_gemma":[0.001246469,0.0002052775,0.0001562254,0.000182876,0.0001322106,0.00001112307,0.0000697497,0.0001549305,0.000002295578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126343,"about_ca_system_score_gemma":0.0002441912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003628693,"about_ca_topic_score_gemma":0.009461852,"domain_scores_codex":[0.9972137,0.0006831696,0.0009827841,0.0006607586,0.00005148382,0.0004081015],"domain_scores_gemma":[0.9983407,0.0002450123,0.0009928872,0.0002517657,0.00008970613,0.00007990664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003711059,0.0001005714,0.9273925,0.00004677656,0.0002330743,1.768112e-7,0.0001072751,0.002716817,0.04961109,0.0001272698,0.001896815,0.01739656],"study_design_scores_gemma":[0.002663324,0.0002590853,0.9809216,0.00006077177,0.0001035427,0.000003489844,0.0001491165,0.01014088,0.001183006,0.003016684,0.001273647,0.0002249013],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503241,0.00689097,0.04028413,0.0009230388,0.000392037,0.0009322065,0.0002179575,0.000006540368,0.00002903341],"genre_scores_gemma":[0.9890807,0.00543386,0.004242218,0.00008794214,0.0001332958,0.0003236273,0.0002817768,0.00002243103,0.0003942092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05352909,"threshold_uncertainty_score":0.8370975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538365111797392,"score_gpt":0.3241952577189317,"score_spread":0.2988116066009578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}