{"id":"W2995750067","doi":"10.1128/msphere.00796-19","title":"Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction","year":2019,"lang":"en","type":"article","venue":"mSphere","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Deutsche Forschungsgemeinschaft","keywords":"Fumarase; Citric acid cycle; Salmonella enterica; Pentose phosphate pathway; Biochemistry; Biology; Glycolysis; Glycogen; Tricarboxylic acid; Metabolic pathway; Metabolism; Fumarate reductase; Metabolome; Microbiology; Mitochondrion; Enzyme; Succinate dehydrogenase; Metabolite; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006708604,0.0003916421,0.0001706297,0.0001585047,0.00009490223,0.0001432091,0.0001334976,0.000157568,0.0005904448],"category_scores_gemma":[0.0001057026,0.000118852,0.0001412438,0.0001457078,0.0002007416,0.00008872859,0.0001616581,0.0002097877,0.0001485909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014699,"about_ca_system_score_gemma":0.0002493286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125545,"about_ca_topic_score_gemma":0.002343936,"domain_scores_codex":[0.9999093,0.00001936565,0.000008631892,0.00001847196,0.00002064998,0.00002365291],"domain_scores_gemma":[0.99989,0.0000147258,0.00004083606,0.00001107321,0.00000950462,0.00003380002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001720044,0.0000135834,0.0001670976,0.00001326248,0.000003893707,0.00002088454,0.000004239085,0.00007075101,0.9991834,0.0000349212,0.000007146109,0.0003089275],"study_design_scores_gemma":[0.00001443832,0.0003922578,0.005740636,0.000004277773,0.00001882157,0.00009798557,0.00002355186,0.00104558,0.9920436,0.00004981105,0.0005647434,0.000004405842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982053,0.0002979274,0.0009169323,0.00004075513,0.000008786003,0.000009040208,0.0001923966,0.00003266242,0.000296136],"genre_scores_gemma":[0.9976197,0.0003430398,0.001193472,0.00002208494,0.000002951066,0.0000134389,0.0003397048,0.00001524625,0.0004504257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125545,"threshold_uncertainty_score":0.002496302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005649223017620116,"score_gpt":0.2274222310811777,"score_spread":0.2217730080635575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}