{"id":"W2995799421","doi":"10.1002/jbmr.3937","title":"Genetically Decreased Circulating Vascular Endothelial Growth Factor and Osteoporosis Outcomes: A Mendelian Randomization Study","year":2019,"lang":"en","type":"review","venue":"Journal of Bone and Mineral Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Femoral neck; Mendelian randomization; Osteoporosis; Internal medicine; Vascular endothelial growth factor; Bone mineral; Confidence interval; Odds ratio; Bone density; Endocrinology; VEGF receptors; Biology; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007811766,0.001230188,0.001807512,0.0007120346,0.0007216006,0.0007531788,0.001018181,0.001569591,0.002291654],"category_scores_gemma":[0.01902302,0.0007734298,0.003549342,0.001365892,0.0007462561,0.0004141031,0.0004727978,0.0008787727,0.0002369653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006158087,"about_ca_system_score_gemma":0.0007385092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00460068,"about_ca_topic_score_gemma":0.003035807,"domain_scores_codex":[0.9904318,0.005344604,0.0007040953,0.002305271,0.0008792534,0.0003349451],"domain_scores_gemma":[0.9946707,0.002511317,0.0009954979,0.001337017,0.0003249421,0.0001605402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1192023,0.00195969,0.6786379,0.002846335,0.1004211,0.006225958,0.0008164638,0.006366515,0.01948187,0.009408807,0.006875053,0.04775807],"study_design_scores_gemma":[0.08683374,0.01782904,0.6385804,0.0006336915,0.1610705,0.01152748,0.0002911684,0.04936061,0.004909442,0.01754628,0.01094023,0.0004773971],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9750405,0.005035357,0.01573366,0.0005896356,0.0002316661,0.0007113079,0.001571479,0.0001780602,0.0009084056],"genre_scores_gemma":[0.9913537,0.0004502415,0.006263494,0.0003483627,0.0000624588,0.0004662213,0.000602838,0.00002702879,0.000425633],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007811766,"threshold_uncertainty_score":0.04131305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0833144773548176,"score_gpt":0.3931343109191172,"score_spread":0.3098198335642995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}