{"id":"W2995808512","doi":"10.1056/nejmoa1914609","title":"Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1313,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Seattle Genetics","keywords":"Capecitabine; Trastuzumab; Metastatic breast cancer; Oncology; Medicine; Internal medicine; Breast cancer; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007405127,0.0002854768,0.000698059,0.0002986777,0.000162619,0.0002410457,0.0002230645,0.000413674,0.002366028],"category_scores_gemma":[0.001162027,0.0001025143,0.0003365923,0.000267299,0.0002723314,0.0001608192,0.0001744282,0.0005163798,0.0001970014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004570871,"about_ca_system_score_gemma":0.0005949184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005207922,"about_ca_topic_score_gemma":0.00166682,"domain_scores_codex":[0.9996208,0.0001932015,0.00003446153,0.00004834149,0.00005970761,0.00004353122],"domain_scores_gemma":[0.9997553,0.00007466535,0.00006965219,0.00001116641,0.00001085881,0.00007844071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3538754,0.007371324,0.0171454,0.002709212,0.001563231,0.0007596551,0.0001294401,0.004554329,0.01566115,0.00134424,0.00544341,0.5894431],"study_design_scores_gemma":[0.5757533,0.2708189,0.095662,0.0007289834,0.002557074,0.003599963,0.0001253536,0.005217191,0.006283418,0.002293845,0.03688997,0.0000698872],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728823,0.0211024,0.0004367192,0.0007691212,0.0002112062,0.0009570416,0.0001565227,0.00003194705,0.003452716],"genre_scores_gemma":[0.9924465,0.005068997,0.0004704933,0.0003682342,0.000166119,0.0005445176,0.0001738361,0.000002166016,0.0007592456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002366028,"threshold_uncertainty_score":0.007915199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03135860786207033,"score_gpt":0.3704714722607771,"score_spread":0.3391128643987068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}