{"id":"W2995903718","doi":"10.1093/cercor/bhz270","title":"Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence","year":2019,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital","funders":"H2020 European Research Council; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Medical Research Council; Royal Perth Hospital Medical Research Foundation; Fondation pour la Recherche Médicale; Svenska Forskningsrådet Formas; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Institutes of Health; Science Foundation Ireland; National Alliance for Research on Schizophrenia and Depression; California Department of Fish and Game","keywords":"Genome-wide association study; Neurocognitive; Insula; Anterior cingulate cortex; Endophenotype; Prefrontal cortex; Psychology; Neuroscience; Single-nucleotide polymorphism; Biology; Genetics; Genotype; Cognition; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001521822,0.00135435,0.0005500676,0.001132017,0.0002995587,0.001211736,0.000556812,0.0005686643,0.002949993],"category_scores_gemma":[0.00674322,0.0004697937,0.001333821,0.001139532,0.0009255762,0.000446292,0.001169524,0.0007988517,0.000228184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003519581,"about_ca_system_score_gemma":0.0004055875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01165278,"about_ca_topic_score_gemma":0.009517589,"domain_scores_codex":[0.9988986,0.0003597031,0.0000674952,0.0003837986,0.0001524285,0.0001378841],"domain_scores_gemma":[0.9966619,0.001430063,0.000814827,0.0006935154,0.000201972,0.0001977548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009013664,0.00006981144,0.9631913,0.0001039961,0.003857785,0.0003113435,0.0002915876,0.001155052,0.01017964,0.0007480597,0.0003363581,0.01885386],"study_design_scores_gemma":[0.00002116711,0.00007754008,0.9961816,0.00001195069,0.0006569022,0.0001186161,0.00005275449,0.001064761,0.0006735136,0.000960782,0.0001718252,0.000008606901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939889,0.001043246,0.002943662,0.0001905645,0.00001349033,0.00001411953,0.0004604655,0.00009913228,0.001246374],"genre_scores_gemma":[0.9981153,0.0002379264,0.001029357,0.00003810888,0.00001239883,0.00001049463,0.0002997212,0.00001619485,0.0002406386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01165278,"threshold_uncertainty_score":0.02316988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04168888361454447,"score_gpt":0.3062676678831504,"score_spread":0.2645787842686059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}