{"id":"W2995980878","doi":"10.1007/s10354-019-00721-5","title":"Romosozumab: a novel bone anabolic treatment option for osteoporosis?","year":2019,"lang":"en","type":"article","venue":"Wiener Medizinische Wochenschrift","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medizinische Universität Wien; European Commission","keywords":"Sclerostin; Medicine; Osteoporosis; Bone remodeling; Anabolism; Bone resorption; Internal medicine; Bone formation; Bone mineral; Wnt signaling pathway; Endocrinology; Bioinformatics; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750931,0.000257852,0.0003690062,0.0004332716,0.0001331507,0.0003753325,0.0002113968,0.0005668028,0.003658802],"category_scores_gemma":[0.0001248457,0.00009058489,0.0003096584,0.0002448577,0.0002457757,0.0003829136,0.0001632071,0.0007492697,0.001862123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985898,"about_ca_system_score_gemma":0.0001776647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002501162,"about_ca_topic_score_gemma":0.0008726768,"domain_scores_codex":[0.9999379,0.00001231641,0.000004609743,0.00001488875,0.00001675113,0.00001346592],"domain_scores_gemma":[0.9999702,0.000004827519,0.000008376312,0.000002166905,0.000005186092,0.000009164841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002073042,0.0004743482,0.001230647,0.001190635,0.00008460143,0.002199645,0.00006749389,0.0002054591,0.09087437,0.006067023,0.01589587,0.879637],"study_design_scores_gemma":[0.003231119,0.005990845,0.0164844,0.0007951987,0.000289673,0.02256872,0.0001148345,0.001521468,0.04036946,0.007423041,0.9011028,0.0001084845],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1171609,0.8176934,0.007213965,0.02179484,0.00199613,0.0001696466,0.0005662757,0.000485354,0.03291944],"genre_scores_gemma":[0.4930782,0.4398749,0.01195705,0.009945623,0.002271775,0.0002126429,0.001091889,0.00005975886,0.04150823],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003658802,"threshold_uncertainty_score":0.01223993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220678732745889,"score_gpt":0.2544018868986136,"score_spread":0.2421950995711548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}