{"id":"W2995989799","doi":"10.1126/sciadv.aax7331","title":"Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Dementia; Sleep (system call); Cognitive impairment; Cognition; Neuroscience; Medicine; Cognitive decline; Microglia; Memory impairment; Brain aging; Psychology; Gerontology; Disease; Inflammation; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004591194,0.000288089,0.0003211615,0.0008859079,0.0004228097,0.0004306373,0.000236481,0.0004082007,0.0007665688],"category_scores_gemma":[0.00104563,0.0001987703,0.0002758942,0.0006503549,0.0002955218,0.0003871017,0.0005122943,0.0003771486,0.000097063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886527,"about_ca_system_score_gemma":0.0002148459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008412636,"about_ca_topic_score_gemma":0.01539009,"domain_scores_codex":[0.9998461,0.00003261844,0.00002635342,0.00003612744,0.00003124054,0.00002760409],"domain_scores_gemma":[0.9994697,0.00004479659,0.0003048409,0.00003266368,0.00004639829,0.0001016408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007294836,0.000136339,0.9946566,0.00003345451,0.0001154108,0.000176209,0.0002683583,0.00003448506,0.0006526871,0.00002608605,0.00009120553,0.003079862],"study_design_scores_gemma":[0.000006212277,0.00009433641,0.999592,0.000005522606,0.00001332084,0.0001042493,0.0000840434,0.00002903385,0.00001368608,0.0000205957,0.00003576674,0.000001301916],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984188,0.001085188,0.00002288981,0.00004052855,0.000004615478,0.000006380193,0.0001267763,0.000001491098,0.0002933783],"genre_scores_gemma":[0.9992127,0.0003690682,0.00004421682,0.00003333376,0.00001353928,0.000007075952,0.0001677805,6.161425e-7,0.0001515369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008412636,"threshold_uncertainty_score":0.01672733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274025465640811,"score_gpt":0.2763847959910487,"score_spread":0.2636445413346406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}