{"id":"W2995994433","doi":"10.1038/s41589-019-0427-y","title":"Tailor-made GPCRs","year":2019,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"In silico; G protein-coupled receptor; Computational biology; Allosteric regulation; Sequence (biology); Biology; Bioinformatics; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002401705,0.000512796,0.0005300971,0.0002648631,0.001217744,0.002092138,0.0008927117,0.009606035,0.006191411],"category_scores_gemma":[0.005163602,0.0004279348,0.0004932287,0.0002418124,0.002679376,0.001869105,0.001484531,0.01251146,0.00536055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002125936,"about_ca_system_score_gemma":0.001012868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000821762,"about_ca_topic_score_gemma":0.001733235,"domain_scores_codex":[0.9988171,0.00016888,0.00006068504,0.0001203017,0.0005904054,0.000242624],"domain_scores_gemma":[0.9988008,0.0004764954,0.0000860941,0.000164463,0.0001719422,0.0003003006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002756559,0.00006472543,0.0002758253,0.0001247211,0.00003110694,0.001348447,0.0001005001,0.0003643746,0.009197606,0.1191589,0.8320174,0.03704082],"study_design_scores_gemma":[0.000106583,0.00008933468,0.00020105,0.00003032869,0.00001208859,0.0003642786,0.00004120259,0.0006032246,0.005859793,0.02931285,0.9633496,0.00002952605],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.007978087,0.0171672,0.005830554,0.7804689,0.1250915,0.00008562034,0.0004632208,0.0008508795,0.06206406],"genre_scores_gemma":[0.1404334,0.01386339,0.00412895,0.6488366,0.04854967,0.0002614016,0.0003880446,0.0002600762,0.1432785],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.009606035,"threshold_uncertainty_score":0.02071232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006122944005216174,"score_gpt":0.2432430715676117,"score_spread":0.2371201275623955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}