{"id":"W2995994433","doi":"10.1038/s41589-019-0427-y","title":"Tailor-made GPCRs","year":2019,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"In silico; G protein-coupled receptor; Computational biology; Allosteric regulation; Sequence (biology); Biology; Bioinformatics; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001304967,0.0004933937,0.0005302611,0.00006999007,0.00003875249,0.0000237708,0.0007233946,0.01008077,0.0005150526],"category_scores_gemma":[0.000211604,0.0004156413,0.0003642993,0.00008348174,0.0001287415,0.000001629893,0.0002841591,0.003790101,0.0001862955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000034529,"about_ca_system_score_gemma":0.0001036153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003954995,"about_ca_topic_score_gemma":3.225412e-7,"domain_scores_codex":[0.9977238,0.0000938216,0.000322042,0.001050146,0.0001592,0.0006509564],"domain_scores_gemma":[0.9988886,0.0000631403,0.0001816214,0.0006876356,0.0001160633,0.00006299089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001771824,0.000006257949,0.00001469695,0.0000275945,0.00006067377,0.000007749331,0.000001550689,1.818212e-7,0.5225546,0.00003844053,0.476928,0.0003424616],"study_design_scores_gemma":[0.0001758056,0.00008684277,5.484056e-7,0.00001300168,0.00001949505,0.00002000092,0.000001409017,0.00000146694,0.4339104,0.000281455,0.5651881,0.0003015631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1416491,0.03498689,0.001552496,0.7792419,0.01661591,0.002174354,0.001360807,0.0003084194,0.02211005],"genre_scores_gemma":[0.04941493,0.0003261353,0.001202727,0.9103259,0.01802997,0.00004721948,0.01381272,0.0001482375,0.006692139],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.131084,"threshold_uncertainty_score":0.9998295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006122944005216174,"score_gpt":0.2432430715676117,"score_spread":0.2371201275623955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}