{"id":"W2996057910","doi":"10.1007/s00401-019-02110-z","title":"Overlapping genetic architecture between Parkinson disease and melanoma","year":2019,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Medical Research Council; Melvin and Bren Simon Cancer Center, Indiana University; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Melanoma Institute Australia; Centre hospitalier régional universitaire de Lille; National Institute on Aging; Menzies Institute for Medical Research; Flinders University; Conservatoire National des Arts et Métiers; Deutschen Konsortium für Translationale Krebsforschung; Hjartavernd; Pomorski Uniwersytet Medyczny W Szczecinie; Tianjin Medical University; Agence Nationale de la Recherche; Assistance publique-Hôpitaux de Paris; Alzheimer's Association; Université Sorbonne Paris Cité; Karolinska Institutet; Université Paris 13; Universitat de Barcelona; Université Paris Descartes; University of Texas MD Anderson Cancer Center; National and Kapodistrian University of Athens; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Università degli Studi di Genova; Tel Aviv University; QIMR Berghofer Medical Research Institute; Lunds Universitet; Erasmus Medisch Centrum; Haukeland Universitetssjukehus; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Hope Center for Neurological Disorders; Institut National de la Santé et de la Recherche Médicale; Universiteit Leiden; Moffitt Cancer Center; University of Glasgow; Brown University; Bundesministerium für Bildung und Forschung; McGill University; University of Leeds; Queensland University of Technology; Institut National de la Recherche Agronomique; Wellcome Trust; Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia; Cancer Research UK; Université de Lille; University of Pennsylvania; Universitetet i Bergen; Génome Québec; Université Paris Diderot; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Deutsches Krebsforschungszentrum; Dartmouth College; University of Tasmania","keywords":"Melanoma; Genetic architecture; Linkage disequilibrium; Genome-wide association study; Genetic association; Correlation; Disease; Biology; Genetics; Parkinson's disease; Genetic correlation; Gene; Genetic variation; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine; Quantitative trait locus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007519326,0.0002307437,0.0003227572,0.0000851818,0.00007736588,0.00002937642,0.0000901729,0.00006724155,0.0001290617],"category_scores_gemma":[0.00008440958,0.0001707483,0.00009418461,0.0001040941,0.00004560888,0.00004095009,0.0001102442,0.0001770771,0.0001056308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001882329,"about_ca_system_score_gemma":0.00003290941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002455011,"about_ca_topic_score_gemma":1.815194e-7,"domain_scores_codex":[0.998637,0.0001194986,0.0001627259,0.0005648065,0.0002069519,0.0003089959],"domain_scores_gemma":[0.999021,0.00008101446,0.00007259673,0.0004190081,0.00002007529,0.0003863187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002273451,0.0001350448,0.9558063,0.0000796617,0.0000482509,0.002561156,0.00005012758,0.000002308256,0.02051064,0.00003228488,0.0000578241,0.02048909],"study_design_scores_gemma":[0.001016742,0.0005070493,0.9682854,0.00004654513,0.0002350495,0.0001464746,0.000007619372,0.00004218641,0.0002327251,0.0003857689,0.02893368,0.000160706],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966659,0.0006149397,0.00006818555,0.0006188925,0.00009153668,0.0005250812,0.00004691611,0.0001145791,0.001253992],"genre_scores_gemma":[0.9976303,0.0002148311,0.0007767215,0.0008741163,0.0001146826,0.00002280649,0.00003234103,0.00003071696,0.0003035018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02887586,"threshold_uncertainty_score":0.6962912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522829277975579,"score_gpt":0.2381847968607561,"score_spread":0.2229565040810003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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