{"id":"W2996057910","doi":"10.1007/s00401-019-02110-z","title":"Overlapping genetic architecture between Parkinson disease and melanoma","year":2019,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Medical Research Council; Melvin and Bren Simon Cancer Center, Indiana University; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Melanoma Institute Australia; Centre hospitalier régional universitaire de Lille; National Institute on Aging; Menzies Institute for Medical Research; Flinders University; Conservatoire National des Arts et Métiers; Deutschen Konsortium für Translationale Krebsforschung; Hjartavernd; Pomorski Uniwersytet Medyczny W Szczecinie; Tianjin Medical University; Agence Nationale de la Recherche; Assistance publique-Hôpitaux de Paris; Alzheimer's Association; Université Sorbonne Paris Cité; Karolinska Institutet; Université Paris 13; Universitat de Barcelona; Université Paris Descartes; University of Texas MD Anderson Cancer Center; National and Kapodistrian University of Athens; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Università degli Studi di Genova; Tel Aviv University; QIMR Berghofer Medical Research Institute; Lunds Universitet; Erasmus Medisch Centrum; Haukeland Universitetssjukehus; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Hope Center for Neurological Disorders; Institut National de la Santé et de la Recherche Médicale; Universiteit Leiden; Moffitt Cancer Center; University of Glasgow; Brown University; Bundesministerium für Bildung und Forschung; McGill University; University of Leeds; Queensland University of Technology; Institut National de la Recherche Agronomique; Wellcome Trust; Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia; Cancer Research UK; Université de Lille; University of Pennsylvania; Universitetet i Bergen; Génome Québec; Université Paris Diderot; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Deutsches Krebsforschungszentrum; Dartmouth College; University of Tasmania","keywords":"Melanoma; Genetic architecture; Linkage disequilibrium; Genome-wide association study; Genetic association; Correlation; Disease; Biology; Genetics; Parkinson's disease; Genetic correlation; Gene; Genetic variation; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine; Quantitative trait locus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000289886,0.0006327845,0.0004496209,0.002125625,0.0007797575,0.0007901423,0.0005427736,0.0009639031,0.00545849],"category_scores_gemma":[0.001198239,0.0004163317,0.0005632543,0.001040386,0.0006896375,0.0004961069,0.0009939863,0.0006456917,0.0003580463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979281,"about_ca_system_score_gemma":0.0004347113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002169578,"about_ca_topic_score_gemma":0.0024019,"domain_scores_codex":[0.9993201,0.000161386,0.00007070538,0.0002115677,0.0001414792,0.00009457898],"domain_scores_gemma":[0.9988688,0.0003377628,0.0004719232,0.0001111069,0.0001045076,0.0001059158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004791893,0.0005649151,0.4048215,0.0005375204,0.001398666,0.08862418,0.001744506,0.001847251,0.4227003,0.02025301,0.001918179,0.05079805],"study_design_scores_gemma":[0.0002733658,0.0007593313,0.8263523,0.0002918741,0.001110888,0.1157197,0.001244954,0.003030647,0.02981389,0.01406031,0.007233884,0.0001088409],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888198,0.002246424,0.001782348,0.0005951971,0.00005530385,0.00003330619,0.0005701774,0.00006311821,0.005834247],"genre_scores_gemma":[0.9968105,0.0007487247,0.0008918953,0.00008367497,0.00004221066,0.0000114116,0.0002313354,0.00001660318,0.001163722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00545849,"threshold_uncertainty_score":0.01826054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522829277975579,"score_gpt":0.2381847968607561,"score_spread":0.2229565040810003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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