{"id":"W2996066981","doi":"10.1136/gutjnl-2019-318934","title":"Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial","year":2019,"lang":"en","type":"article","venue":"Gut","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":723,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Bayer Yakuhin","keywords":"Sorafenib; Medicine; Hepatocellular carcinoma; Internal medicine; Clinical endpoint; Gastroenterology; Adverse effect; Response Evaluation Criteria in Solid Tumors; Progression-free survival; Oncology; Randomized controlled trial; Clinical trial; Overall survival; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002534465,0.0003935375,0.001212417,0.0001783078,0.000052018,0.00002984293,0.0001081893,0.0001926501,0.0001893354],"category_scores_gemma":[0.00005222673,0.0002909586,0.0001832251,0.0003359488,0.00009388485,0.0001917256,0.00001726015,0.0002445651,0.00004741419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824954,"about_ca_system_score_gemma":0.0004242749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003693898,"about_ca_topic_score_gemma":0.00005478907,"domain_scores_codex":[0.9975169,0.0001776413,0.0006366317,0.0005337395,0.0007245548,0.0004105183],"domain_scores_gemma":[0.9986432,0.0001182262,0.0003477993,0.0004487252,0.0002691881,0.0001728782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5417256,0.001294856,0.4545598,0.00008576478,0.0001709734,0.00004412698,0.001641578,0.000007688124,0.0003553306,0.000006320224,0.000007851797,0.0001001244],"study_design_scores_gemma":[0.9289415,0.008506479,0.04953874,0.0001292039,0.0007554614,0.00000517999,0.0002947251,0.002049278,0.009375988,0.000006718822,0.00007745915,0.0003192176],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833059,0.00005758183,0.00006526379,0.00008419535,0.0003379843,0.0154449,0.0000287189,0.00004344638,0.0006319604],"genre_scores_gemma":[0.9983442,0.000005057713,0.0004585682,0.00002278335,0.0002164446,0.0002940057,0.0003812668,0.00006038966,0.0002172327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.405021,"threshold_uncertainty_score":0.9999543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871837646052252,"score_gpt":0.2217589412652851,"score_spread":0.2030405648047626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}