{"id":"W2996102639","doi":"10.1021/acs.molpharmaceut.9b00986","title":"Radiosynthesis and Biological Evaluation of [<sup>18</sup>F]Triacoxib: A New Radiotracer for PET Imaging of COX-2","year":2019,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Cancer Foundation","keywords":"Radiosynthesis; Chemistry; In vivo; Positron emission tomography; Preclinical imaging; Celecoxib; Molecular imaging; Radiochemistry; Nuclear medicine; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001399424,0.0001712483,0.0004547008,0.0001252227,0.00002277344,0.000006336245,0.00007404526,0.00007366257,0.0002143883],"category_scores_gemma":[0.000448402,0.0001456795,0.0001546437,0.0001263025,0.00008137069,0.00004263675,0.00003122916,0.0001279888,0.000005246479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005839163,"about_ca_system_score_gemma":0.0002030661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005999465,"about_ca_topic_score_gemma":1.115352e-7,"domain_scores_codex":[0.9985616,0.0001860197,0.0003479516,0.0002475651,0.0004195912,0.00023734],"domain_scores_gemma":[0.99896,0.0002421377,0.0001611171,0.0002366353,0.0002360891,0.0001640488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008373643,0.0001553389,0.03228918,0.0007773491,0.0003038274,0.00003277278,0.0004473987,0.0008382491,0.9222888,0.0002114242,0.0007181137,0.04110023],"study_design_scores_gemma":[0.008740004,0.0002634092,0.002215846,0.000162708,0.001114556,0.00009684943,0.00009622667,0.2783084,0.7045523,0.0001432898,0.004105586,0.0002008263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926615,0.003270345,0.001641958,0.0002232874,0.000130285,0.001681692,0.00001740421,0.00002177438,0.000351701],"genre_scores_gemma":[0.9970259,0.0001484286,0.002361734,0.0002489581,0.0001020337,0.00002467747,0.00001933107,0.00002969439,0.00003921418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2774702,"threshold_uncertainty_score":0.5940638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05430639588185659,"score_gpt":0.3625520141781572,"score_spread":0.3082456182963006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}