{"id":"W2996130218","doi":"10.1097/j.pain.0000000000001780","title":"Detangling red hair from pain: phenotype-specific contributions from different genetic variants in melanocortin-1 receptor","year":2019,"lang":"en","type":"article","venue":"Pain","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Dental and Craniofacial Research","keywords":"Allele; Melanocortin 1 receptor; Locus (genetics); Minor allele frequency; Genetics; Erythromelalgia; Haplotype; Medicine; Missense mutation; Biology; Phenotype; Allele frequency; Dermatology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008608535,0.000569852,0.0005114136,0.0007488035,0.000258837,0.0004924749,0.0003748367,0.0004272977,0.002467633],"category_scores_gemma":[0.001919858,0.0002463411,0.0006600501,0.0004792908,0.0004250678,0.0002350282,0.0005042391,0.0006724608,0.0001603378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001058416,"about_ca_system_score_gemma":0.0001232215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608689,"about_ca_topic_score_gemma":0.001964167,"domain_scores_codex":[0.9991434,0.0002306925,0.00007471242,0.0003026667,0.0001682295,0.00008037304],"domain_scores_gemma":[0.9988061,0.0005454713,0.0002972494,0.0001622685,0.00005799502,0.0001309618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003888539,0.0002209386,0.7248609,0.0001335185,0.0008612546,0.005462522,0.001004916,0.000386843,0.2433965,0.0004276826,0.0003107821,0.01904548],"study_design_scores_gemma":[0.00004156022,0.0001689519,0.9949387,0.000008206599,0.0001056473,0.002623357,0.00006165559,0.0003825068,0.00135985,0.0001628994,0.0001365004,0.00001017131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988521,0.0001953353,0.0005327205,0.00003572214,0.000006088087,0.000007379143,0.0001286428,0.000009826119,0.0002321654],"genre_scores_gemma":[0.9991232,0.0000587924,0.0004282383,0.00003931754,0.00001015739,0.00000695535,0.0001053011,0.00001506213,0.000212983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002467633,"threshold_uncertainty_score":0.008255064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007693050999101549,"score_gpt":0.2196427752097053,"score_spread":0.2119497242106037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}