{"id":"W2996166277","doi":"10.1016/j.jval.2019.09.332","title":"PCN136 ECONOMIC VIABILITY OF CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOR ADULTS WITH ADVANCED LEUKEMIA: EVIDENCE FROM AN EARLY ECONOMIC MODELLING","year":2019,"lang":"en","type":"article","venue":"Value in Health","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Medicine; Blinatumomab; Chimeric antigen receptor; Oncology; Immunotherapy; Salvage therapy; Internal medicine; Leukemia; Chemotherapy; Cancer; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007504018,0.001195082,0.001573942,0.0007640273,0.0002636299,0.00187637,0.001468686,0.001282051,0.007166503],"category_scores_gemma":[0.02041693,0.0005160681,0.002694395,0.0009265049,0.0008675638,0.001228135,0.000869911,0.002731202,0.0003954709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005372456,"about_ca_system_score_gemma":0.004155518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02494953,"about_ca_topic_score_gemma":0.01123138,"domain_scores_codex":[0.9968442,0.00234963,0.00007589435,0.0001270938,0.0002743896,0.0003288128],"domain_scores_gemma":[0.9750811,0.02306658,0.0007832451,0.0003444043,0.0004248135,0.000299885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03028854,0.001202406,0.009571586,0.002211303,0.002824104,0.0003031316,0.0001648008,0.807192,0.0004825033,0.04754155,0.007879164,0.0903388],"study_design_scores_gemma":[0.01344134,0.01099221,0.01676355,0.001700654,0.009431546,0.0002856041,0.0004115858,0.8251567,0.002651411,0.08913185,0.02982086,0.000212701],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8568987,0.02905906,0.02909974,0.009612788,0.0005490181,0.001268105,0.0106743,0.0001520653,0.06268615],"genre_scores_gemma":[0.9900746,0.003586441,0.001613374,0.000228486,0.00004652815,0.0001867712,0.0007049242,0.00002049801,0.003538391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02494953,"threshold_uncertainty_score":0.04960859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04991998451427404,"score_gpt":0.3305168797348542,"score_spread":0.2805968952205801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}