{"id":"W2996176022","doi":"10.1080/10837450.2019.1705485","title":"Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes","year":2019,"lang":"en","type":"article","venue":"Pharmaceutical Development and Technology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Crohn's and Colitis Canada","keywords":"Glioma; Gene silencing; Viability assay; Small interfering RNA; Cancer research; Oligonucleotide; Cancer cell; Chemistry; RNA interference; Cell; Pharmacology; Cancer; Biology; Medicine; RNA; Biochemistry; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236133,0.000189661,0.00022842,0.0001498876,0.00006311882,0.00001438099,0.00009405712,0.0002070086,0.00001404347],"category_scores_gemma":[0.0000101985,0.0001630647,0.0000153439,0.0001025081,0.0001183128,0.000007707696,0.0002381311,0.0001122427,0.00001384405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001240527,"about_ca_system_score_gemma":0.00004544781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.813869e-7,"about_ca_topic_score_gemma":4.257931e-7,"domain_scores_codex":[0.9990383,0.00002402937,0.0002420767,0.0003754242,0.0001011169,0.0002190596],"domain_scores_gemma":[0.9996802,0.00001793958,0.00007009973,0.0001158657,0.00004375977,0.00007213896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919645,0.00003840808,0.005903497,0.00009870303,0.00005761723,0.000003899671,0.00004732516,5.535113e-8,0.8967766,0.00008013241,0.00001233957,0.09678946],"study_design_scores_gemma":[0.0008969658,0.0004068839,0.008173444,0.00005414315,0.00001336024,0.00002279438,0.00002098506,0.00001202847,0.9643673,0.000007348095,0.02584228,0.0001824717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988115,0.0004566332,0.00005916764,0.0001271722,0.00009858945,0.000259359,0.00000351158,0.00002151583,0.0001625912],"genre_scores_gemma":[0.9980994,0.0002612912,0.001198937,0.0001453887,0.00001892038,0.00002509964,0.00006079477,0.00001217885,0.000177915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09660698,"threshold_uncertainty_score":0.6649586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024337615665169,"score_gpt":0.2468295597902327,"score_spread":0.236586183633581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}