{"id":"W2996279625","doi":"10.1128/mbio.02608-19","title":"A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Government of Canada; Once Upon A Time Foundation","keywords":"Vibrio parahaemolyticus; Virulence; Effector; Microbiology; Pathogen; Type three secretion system; Secretion; Biology; Intracellular parasite; Outbreak; Intracellular; Virology; Bacteria; Immunology; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231995,0.0001303913,0.0002106891,0.00005019088,0.00003894262,0.00002611571,0.00008972773,0.0000883788,0.000004421249],"category_scores_gemma":[0.0000432177,0.00009342295,0.00003643202,0.00006943115,0.00005229764,0.00001022214,0.0002058655,0.00007620957,0.000009243038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004309263,"about_ca_system_score_gemma":0.00002303863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241447,"about_ca_topic_score_gemma":0.0002367289,"domain_scores_codex":[0.9991519,0.00008470893,0.0001728032,0.0002558391,0.0001282942,0.0002064282],"domain_scores_gemma":[0.9995472,0.00001386986,0.00009014321,0.0002489229,0.0000594673,0.00004043506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002609171,0.00003613585,0.02388037,0.0001711459,0.0000260794,6.245965e-7,0.0001678897,0.0001002014,0.9751555,0.000007610933,0.00006339635,0.0001301378],"study_design_scores_gemma":[0.002547626,0.00139882,0.05542525,0.0003903248,0.00002710908,0.00004814054,0.0002787276,0.009137025,0.9301822,0.00000759898,0.000328054,0.0002291364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982808,0.0001570625,0.0007399211,0.00004874953,0.00006993047,0.0005564818,0.00005033589,0.00000966126,0.00008705067],"genre_scores_gemma":[0.9991339,0.0001927162,0.0001261002,0.00002123894,0.00003450536,0.00003033848,0.00006285695,0.00001575487,0.0003826106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0449733,"threshold_uncertainty_score":0.3809678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312465126205152,"score_gpt":0.2398238172917317,"score_spread":0.2266991660296802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}