{"id":"W2996279625","doi":"10.1128/mbio.02608-19","title":"A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Government of Canada; Once Upon A Time Foundation","keywords":"Vibrio parahaemolyticus; Virulence; Effector; Microbiology; Pathogen; Type three secretion system; Secretion; Biology; Intracellular parasite; Outbreak; Intracellular; Virology; Bacteria; Immunology; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004301868,0.001901626,0.0006348717,0.001858863,0.0005667944,0.0007740946,0.0008069213,0.002139868,0.004315153],"category_scores_gemma":[0.0002261936,0.0006089598,0.000852457,0.0004202851,0.0009888625,0.0009626031,0.0005491163,0.003189988,0.001139768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007311186,"about_ca_system_score_gemma":0.000430747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008869112,"about_ca_topic_score_gemma":0.001110978,"domain_scores_codex":[0.9993642,0.000075332,0.0000677156,0.0002221593,0.0001208854,0.000149742],"domain_scores_gemma":[0.9995428,0.0000566586,0.0001581572,0.00005867105,0.00003149309,0.0001522543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006767027,0.0005357689,0.0004966051,0.00008046315,0.00002189332,0.0003777836,0.00006217379,0.0001409229,0.9944113,0.001057211,0.0003223748,0.001816818],"study_design_scores_gemma":[0.0005086171,0.004645726,0.008206182,0.0001351555,0.0001614762,0.003782045,0.0002680894,0.004019822,0.9597369,0.001345928,0.0171263,0.0000637699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596655,0.002784128,0.02341123,0.001562101,0.0004980438,0.0002846077,0.005424134,0.0008540871,0.005516153],"genre_scores_gemma":[0.9432905,0.003287708,0.01876032,0.0006760826,0.0001189387,0.0007775951,0.005805248,0.0003131033,0.02697042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004315153,"threshold_uncertainty_score":0.01443565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312465126205152,"score_gpt":0.2398238172917317,"score_spread":0.2266991660296802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}