{"id":"W2996314623","doi":"10.1002/path.5372","title":"Interpretation of somatic <i>POLE</i> mutations in endometrial carcinoma","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency; University of British Columbia","funders":"Health Foundation; Academy of Medical Sciences; KWF Kankerbestrijding; National Institute for Health and Care Research; BC Cancer Foundation; Cancer Research UK; Michael Smith Health Research BC","keywords":"Somatic cell; Interpretation (philosophy); Carcinoma; Endometrial cancer; Internal medicine; Oncology; Medicine; Biology; Genetics; Philosophy; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006492133,0.00005517343,0.0002835496,0.0002492943,0.000007457439,0.000001474799,0.000102221,0.00005018786,0.0001302414],"category_scores_gemma":[0.0004676407,0.00003520794,0.00006839002,0.0002113621,0.0000727859,0.00002969337,0.00002033833,0.0002019811,0.00001204544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005961622,"about_ca_system_score_gemma":0.0001241763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009298136,"about_ca_topic_score_gemma":0.000009844567,"domain_scores_codex":[0.9990613,0.0001959251,0.0004415571,0.00004514918,0.0001642936,0.00009171317],"domain_scores_gemma":[0.9989306,0.0004639946,0.0003281536,0.0001307151,0.0001206278,0.00002591853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002706594,0.0001854706,0.3153487,0.0001349061,0.00006472306,0.0001433878,0.01023891,0.001384581,0.6630995,0.00007266067,0.0001086344,0.006511976],"study_design_scores_gemma":[0.01171563,0.007750821,0.8544366,0.000344916,0.0004495594,0.006638483,0.003219688,0.002248434,0.1094767,0.003500877,0.00007042701,0.0001478755],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971817,0.0004063147,0.0004669469,0.0003119933,0.0006667304,0.0001916596,0.000001742353,0.000001753081,0.0007711731],"genre_scores_gemma":[0.9990692,0.00002229948,0.0006908744,0.0001055275,0.00006376319,0.000001399915,7.256467e-7,0.000006799174,0.00003948354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5536228,"threshold_uncertainty_score":0.1435738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531422504582592,"score_gpt":0.2849622340298432,"score_spread":0.2696480089840173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}