{"id":"W2996401336","doi":"10.1101/871186","title":"A Nanomule Peptide-siRNA Conjugate that Traverses the Intact Blood Brain Barrier and Attenuates Stroke","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Vancouver General Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Centre for Blood Research, University of British Columbia; University of British Columbia; National Institutes of Health; University of Victoria","keywords":"Transcytosis; Gene knockdown; Blood–brain barrier; NOX4; Peptide; Microglia; Conjugate; Medicine; Central nervous system; Pharmacology; Stroke (engine); Cell biology; Chemistry; Neuroscience; Biology; Inflammation; Immunology; Internal medicine; Cell; Gene; Biochemistry; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283082,0.000244878,0.000208058,0.0002241905,0.0001037601,0.0001975752,0.0001457334,0.0003383976,0.001543668],"category_scores_gemma":[0.0001260549,0.0000863345,0.0001091545,0.00008982475,0.0001942432,0.0001465781,0.0001291338,0.0002744058,0.0004541817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114144,"about_ca_system_score_gemma":0.0002257913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003457603,"about_ca_topic_score_gemma":0.0004321729,"domain_scores_codex":[0.9999325,0.000007486715,0.000005187133,0.00001760786,0.00002518476,0.0000119263],"domain_scores_gemma":[0.9999703,0.000007350776,0.000006672882,0.000002744252,0.000004811245,0.000008193755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005657619,0.00002340646,0.00005164405,0.00003465482,0.000003951288,0.0000532046,0.0000066146,0.0001634416,0.9972289,0.000319168,0.0001390328,0.001919318],"study_design_scores_gemma":[0.00001690591,0.0001072383,0.0005432795,0.000003085925,0.000005712326,0.0001672564,0.000003365314,0.001269231,0.9949198,0.0000846367,0.00287661,0.000002761126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622786,0.002090161,0.02649645,0.0004033784,0.000225597,0.0001131853,0.0005199922,0.0002845755,0.007587993],"genre_scores_gemma":[0.9592897,0.0009262821,0.02246075,0.0001513674,0.00005325022,0.000088534,0.0006607187,0.00009793934,0.01627145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543668,"threshold_uncertainty_score":0.005164087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129722818939989,"score_gpt":0.2104995413221529,"score_spread":0.1992023131327531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}