{"id":"W2996431677","doi":"10.1016/j.celrep.2019.11.014","title":"Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; M.S.I. Foundation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Necroptosis; RIPK1; Ubiquitin; Programmed cell death; Deubiquitinating enzyme; Cell biology; Biology; Apoptosis; Phosphorylation; Caspase; Ubiquitin ligase; Post-translational regulation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770003,0.00009956672,0.0001087355,0.00002846823,0.00002681516,0.000009862663,0.00004961273,0.0001265625,0.00005047788],"category_scores_gemma":[0.00001507054,0.0001000119,0.00005111333,0.00003096233,0.00003147346,0.000003863888,0.00003316968,0.00004763382,0.000004982138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005637455,"about_ca_system_score_gemma":0.00006440421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001432407,"about_ca_topic_score_gemma":0.000005820555,"domain_scores_codex":[0.9992166,0.00002355488,0.0002551386,0.0002784816,0.0001063632,0.0001198215],"domain_scores_gemma":[0.9993572,0.00001043253,0.0001869137,0.0002879488,0.0001083206,0.00004914999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002550703,0.00004225645,0.01798625,0.0000883875,0.000006022952,0.000004425103,0.00004946317,0.00006094091,0.9809532,0.0001808676,0.00002773637,0.0005749173],"study_design_scores_gemma":[0.0001744335,0.0001218729,0.008858637,0.00001030976,0.00001084543,0.00004403604,0.00003937175,0.0006474758,0.9886452,0.0003522068,0.0009737277,0.0001219168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866297,0.0005357586,0.0003677038,0.00004348796,0.00007498069,0.0002373285,0.00002669171,0.000008113384,0.01207627],"genre_scores_gemma":[0.99512,0.00005504846,0.00106098,0.00003658679,0.00004106362,0.0000073511,0.0005237345,0.00001538146,0.0031398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009127608,"threshold_uncertainty_score":0.4078368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008548091530327073,"score_gpt":0.2228323217423452,"score_spread":0.2142842302120181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}