{"id":"W2996463763","doi":"10.1093/annonc/mdz453.002","title":"KRAS mutational status and efficacy in KEYNOTE-189: Pembrolizumab (pembro) plus chemotherapy (chemo) vs placebo plus chemo as first-line therapy for metastatic non-squamous NSCLC","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Internal medicine; KRAS; Chemotherapy; Placebo; Cancer; Immunotherapy; Pathology; Alternative medicine; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002861612,0.0003128709,0.0009609829,0.0002578006,0.00007380328,0.00001570281,0.0001130527,0.0001816097,0.0003838641],"category_scores_gemma":[0.0001447429,0.0002664691,0.0001743858,0.0002428188,0.0001491396,0.0001222472,0.00002354977,0.0001882067,0.000033574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264787,"about_ca_system_score_gemma":0.001724259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005050968,"about_ca_topic_score_gemma":0.000151071,"domain_scores_codex":[0.9980583,0.00005709702,0.0005856074,0.0004880414,0.0002704793,0.0005404795],"domain_scores_gemma":[0.9979206,0.0009686046,0.0003001289,0.0003036382,0.0003078516,0.0001991699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.248308,0.01719564,0.01903269,0.002755683,0.006562754,0.0004710802,0.04910231,0.008945302,0.01025669,0.005157129,0.01275082,0.619462],"study_design_scores_gemma":[0.5428581,0.0502464,0.2004266,0.0005297078,0.0009195018,0.000463179,0.001861989,0.01158403,0.0282917,0.005810839,0.1555958,0.001412111],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816711,0.0016052,0.0002429403,0.009147835,0.0001896567,0.003077556,0.00008646309,0.00003384647,0.003945378],"genre_scores_gemma":[0.9902116,0.00179592,0.001766448,0.004015585,0.000105584,0.0003339826,0.0002825966,0.00006115669,0.001427125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6180499,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04250243793272943,"score_gpt":0.408233918926705,"score_spread":0.3657314809939756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}