{"id":"W2996463763","doi":"10.1093/annonc/mdz453.002","title":"KRAS mutational status and efficacy in KEYNOTE-189: Pembrolizumab (pembro) plus chemotherapy (chemo) vs placebo plus chemo as first-line therapy for metastatic non-squamous NSCLC","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Internal medicine; KRAS; Chemotherapy; Placebo; Cancer; Immunotherapy; Pathology; Alternative medicine; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006933635,0.000413631,0.001587947,0.0002304355,0.0001850573,0.0006918658,0.0005062866,0.0009271159,0.00464632],"category_scores_gemma":[0.0008912287,0.0003319872,0.001018231,0.0002338273,0.0004057275,0.0008972868,0.0002576802,0.002361238,0.0005957556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005247796,"about_ca_system_score_gemma":0.0004993025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006332968,"about_ca_topic_score_gemma":0.001479525,"domain_scores_codex":[0.9997258,0.00009312399,0.00002708536,0.00005248435,0.00003108931,0.00007045058],"domain_scores_gemma":[0.9995395,0.0001585398,0.00009830936,0.00002473165,0.00001928952,0.0001596458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9205849,0.006737815,0.003249684,0.0004894136,0.0009025866,0.00007732202,0.00005241693,0.000714378,0.01883051,0.0001584105,0.001439629,0.04676292],"study_design_scores_gemma":[0.3440315,0.5611483,0.07111292,0.0001831971,0.003596568,0.0004592784,0.0001568922,0.002748574,0.01249659,0.0004813399,0.00348901,0.00009576673],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948885,0.002623105,0.00008434284,0.0002965221,0.0001759642,0.0001200194,0.0004523352,0.00003059643,0.001328703],"genre_scores_gemma":[0.9970238,0.0009338026,0.0001163451,0.000211757,0.0001318558,0.00007955691,0.0004413749,0.000006649984,0.001054962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00464632,"threshold_uncertainty_score":0.01554352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04250243793272943,"score_gpt":0.408233918926705,"score_spread":0.3657314809939756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}