{"id":"W2996481369","doi":"10.1002/btpr.2946","title":"Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed‐batch cultures","year":2019,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Glutamine; Asparagine; Ovary; Cysteine; Biochemistry; Biology; Chemistry; Cell culture; Amino acid; Endocrinology; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008923473,0.000628586,0.001076397,0.0003442179,0.0003334542,0.0008730428,0.001084702,0.0006060156,0.0005818043],"category_scores_gemma":[0.0006406194,0.0002696873,0.0005284799,0.0005486314,0.0002745366,0.0003591871,0.0005704775,0.000841204,0.0003360063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009775078,"about_ca_system_score_gemma":0.0006588776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005409085,"about_ca_topic_score_gemma":0.007514194,"domain_scores_codex":[0.9992587,0.0001331082,0.0001365936,0.0001591644,0.0002377714,0.00007466193],"domain_scores_gemma":[0.9994152,0.0001471635,0.00009255276,0.00008412587,0.0001912925,0.00006961182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003185887,0.0001129267,0.0004609749,0.0001293992,0.00001905524,0.00007505331,0.00006168579,0.0002578067,0.9966503,0.00006049042,0.00008835053,0.001765499],"study_design_scores_gemma":[0.0000176811,0.0007713564,0.002412666,0.00001392515,0.00005152739,0.00008655976,0.00004402742,0.001471698,0.9933332,0.00002954353,0.001741672,0.00002619307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884957,0.002144756,0.006002019,0.0001000906,0.0001009618,0.000278867,0.001158487,0.0001379133,0.001581107],"genre_scores_gemma":[0.945907,0.002704824,0.03867687,0.0001817802,0.00003346954,0.0007901983,0.003789781,0.0001439686,0.007772089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005409085,"threshold_uncertainty_score":0.01075524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006228922381896937,"score_gpt":0.2469458152567573,"score_spread":0.2407168928748604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}