{"id":"W2996481369","doi":"10.1002/btpr.2946","title":"Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed‐batch cultures","year":2019,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Glutamine; Asparagine; Ovary; Cysteine; Biochemistry; Biology; Chemistry; Cell culture; Amino acid; Endocrinology; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000635958,0.0002208059,0.0002631672,0.0001352006,0.00004452745,0.00001643554,0.0002049773,0.0005078738,0.000009148292],"category_scores_gemma":[0.00007543893,0.0001608171,0.00006644415,0.000259277,0.0002031069,0.00000891641,0.0002168517,0.0001521274,0.000008794355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008313944,"about_ca_system_score_gemma":0.00003917745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002120189,"about_ca_topic_score_gemma":0.00005575737,"domain_scores_codex":[0.9989056,0.00005451462,0.0002495542,0.0004369914,0.0000938813,0.0002594659],"domain_scores_gemma":[0.9993623,0.0000351536,0.0001262884,0.0003629236,0.00005605539,0.00005731706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004020903,0.0004426254,0.08581296,0.0004886158,0.00005794146,0.00002664895,0.00006594179,0.0000187676,0.9082612,0.00008571785,0.001242692,0.00309485],"study_design_scores_gemma":[0.00302875,0.002665131,0.06105079,0.0001298387,0.00003301687,0.00005055046,0.00009940762,0.0001339833,0.9233851,0.0001929704,0.008817901,0.0004125627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915777,0.006833253,0.00004873857,0.0004246655,0.0001881725,0.000584264,0.00001209696,0.00004396163,0.0002871458],"genre_scores_gemma":[0.9971192,0.0007767766,0.0006538031,0.0001245403,0.00005503804,0.0001112277,0.00004186041,0.00002370856,0.001093808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02476216,"threshold_uncertainty_score":0.6557931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006228922381896937,"score_gpt":0.2469458152567573,"score_spread":0.2407168928748604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}