{"id":"W2996517820","doi":"10.1016/j.cjca.2019.08.033","title":"Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health; University of Toronto; Libin Cardiovascular Institute of Alberta; University of Alberta; St. Michael's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Empagliflozin; Medicine; EMPA; Extracellular matrix; Myofibroblast; Internal medicine; Cardiology; Endocrinology; Cell biology; Diabetes mellitus; Type 2 Diabetes Mellitus; Fibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001354219,0.0002606369,0.001572541,0.001047759,0.00006108108,0.00001499682,0.0001685733,0.0002807186,0.000006382527],"category_scores_gemma":[0.0002634976,0.0002303927,0.000779231,0.0002942401,0.00007010001,0.00008351238,0.00001166092,0.0004945989,0.00001057457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824537,"about_ca_system_score_gemma":0.0005650716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000643514,"about_ca_topic_score_gemma":0.0002403238,"domain_scores_codex":[0.9974223,0.0002237888,0.001178349,0.0003307286,0.0003464547,0.0004983385],"domain_scores_gemma":[0.9980962,0.0003987014,0.0002801613,0.0003667026,0.0002506583,0.0006075255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.001250176,0.00002244594,0.1086741,0.0003598183,0.0005268877,0.0002003777,0.001787211,0.5352272,0.3493348,0.0006230294,0.001156498,0.0008375526],"study_design_scores_gemma":[0.02990248,0.01017923,0.800177,0.01072302,0.00167149,0.001124495,0.001599953,0.004385353,0.05315519,0.0004279632,0.08425371,0.002400077],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906216,0.001868954,0.002519103,0.0005594754,0.001017513,0.0005385027,0.00009332757,0.000007760567,0.002773798],"genre_scores_gemma":[0.9974532,0.00003623914,0.001267142,0.00006450897,0.0007793128,0.000003169262,0.00002374914,0.00004366966,0.0003290334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.691503,"threshold_uncertainty_score":0.939514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014654521783666,"score_gpt":0.2805560894442833,"score_spread":0.2604095442264467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}