{"id":"W2996558754","doi":"10.1016/j.celrep.2019.11.046","title":"Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Imperial College London; Associazione Italiana per la Ricerca sul Cancro; Bryon Riesch Paralysis Foundation; Université Laval; Giovanni Armenise-Harvard Foundation","keywords":"Medulloblastoma; Biology; Progenitor cell; Sonic hedgehog; Chromatin; Cell biology; Neural stem cell; Cellular differentiation; Cell cycle; Neurogenesis; Cancer research; Neuroscience; Stem cell; Cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255812,0.0002736817,0.0002116144,0.00023775,0.0001174263,0.0001617838,0.0001606936,0.0001951496,0.0007179706],"category_scores_gemma":[0.00009944029,0.0001438437,0.0002308344,0.0001005619,0.0001768426,0.0001154808,0.0002063513,0.0002998793,0.000248262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148926,"about_ca_system_score_gemma":0.0001534124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008047666,"about_ca_topic_score_gemma":0.001219493,"domain_scores_codex":[0.9998955,0.00001912557,0.00001306414,0.00001862812,0.00002552478,0.00002815937],"domain_scores_gemma":[0.9998835,0.00002259024,0.00003156575,0.00001769942,0.000005414651,0.00003924512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039752,0.00002003727,0.0002687159,0.00001796018,0.000003820261,0.0000744818,0.00001399919,0.00005181016,0.9987996,0.00004718908,0.00002008914,0.000578394],"study_design_scores_gemma":[0.00001411497,0.0003788029,0.006899172,0.000002961302,0.00001156321,0.0004271369,0.00002803965,0.0006173463,0.9899077,0.00002513058,0.001684978,0.000002950266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979956,0.0004595183,0.0008648557,0.00002639599,0.000006308295,0.00001119331,0.0001814405,0.00005214185,0.0004024699],"genre_scores_gemma":[0.9978004,0.0002760167,0.0006191545,0.00001008239,0.000002390717,0.00001146364,0.0003227589,0.00001239674,0.0009453224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008047666,"threshold_uncertainty_score":0.002401829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002140317754245514,"score_gpt":0.1812866400270721,"score_spread":0.1791463222728266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}