{"id":"W2996558754","doi":"10.1016/j.celrep.2019.11.046","title":"Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Imperial College London; Associazione Italiana per la Ricerca sul Cancro; Bryon Riesch Paralysis Foundation; Université Laval; Giovanni Armenise-Harvard Foundation","keywords":"Medulloblastoma; Biology; Progenitor cell; Sonic hedgehog; Chromatin; Cell biology; Neural stem cell; Cellular differentiation; Cell cycle; Neurogenesis; Cancer research; Neuroscience; Stem cell; Cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009825387,0.0001904487,0.0001729764,0.00003053355,0.00004554775,0.00003973257,0.0001232269,0.0001177753,0.00006072401],"category_scores_gemma":[0.00002355512,0.000156519,0.00005032488,0.0001025904,0.00002494193,0.00000243286,0.00008591948,0.00006097811,0.00005777039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001748325,"about_ca_system_score_gemma":0.0001296377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002319338,"about_ca_topic_score_gemma":0.00005684596,"domain_scores_codex":[0.9988405,0.00001463798,0.0002572613,0.0004901215,0.00013135,0.0002661044],"domain_scores_gemma":[0.998915,0.000002750615,0.0001384781,0.0006088617,0.0001996132,0.0001352543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007566526,0.00007124432,0.006882379,0.00003271978,0.00003329336,0.0000735933,0.00007773557,0.0008288022,0.9907602,0.00001087491,0.0007595586,0.0003939417],"study_design_scores_gemma":[0.0005479374,0.0009807394,0.002669812,0.00003693634,0.0000234474,0.0003206821,0.0000770407,0.0005028359,0.9635462,0.00003562104,0.03081588,0.0004429249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932844,0.00005958182,0.0001819838,0.0000782781,0.0001645462,0.0004982204,0.000005830004,0.00002272604,0.005704446],"genre_scores_gemma":[0.9904058,0.00001428033,0.001807489,0.0003241998,0.00005479824,0.00002923578,0.0001416264,0.00004786861,0.007174726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03005632,"threshold_uncertainty_score":0.638266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002140317754245514,"score_gpt":0.1812866400270721,"score_spread":0.1791463222728266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}