{"id":"W2996576044","doi":"10.1093/braincomms/fcz046","title":"Is tau in the absence of amyloid on the Alzheimer’s continuum?: A study of discordant PET positivity","year":2019,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; University of California, San Francisco; University of California, San Diego; Albert Einstein College of Medicine, Yeshiva University; National Institutes of Health; Rush University; University of Pittsburgh; University of Washington; Johns Hopkins University; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; York University; Northwestern University; University of Pennsylvania; University of Southern California; University of California, Irvine; Yeshiva University; University of California, Davis; Brown University; Brigham and Women's Hospital; National Institute on Aging; Alzheimer's Association; National Science Foundation","keywords":"Tauopathy; Positron emission tomography; Psychology; Temporal lobe; Dementia; Neuroimaging; Alzheimer's disease; Amyloid (mycology); Neurodegeneration; Biomarker; Pathology; Neuroscience; Medicine; Disease; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152871,0.00007180954,0.0001683068,0.00007118152,0.00008229868,0.00001231916,0.000705336,0.0000103762,0.0001249825],"category_scores_gemma":[0.0002087214,0.00003986415,0.00005757531,0.0003176866,0.0002007718,0.00004067102,0.0002428821,0.0002600892,0.00002522561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001084149,"about_ca_system_score_gemma":0.00006117289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004891868,"about_ca_topic_score_gemma":0.0005608552,"domain_scores_codex":[0.9985119,0.000667245,0.0002360292,0.0001120012,0.0003482961,0.000124548],"domain_scores_gemma":[0.9961878,0.001860777,0.0001019457,0.001699063,0.0001293665,0.00002103028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002767871,0.01129471,0.9298291,0.00004458865,0.0004274362,0.00001138446,0.01939797,0.000001003692,0.02253114,0.00739837,0.004988221,0.003799305],"study_design_scores_gemma":[0.001109002,0.00102719,0.9791028,0.0001216898,0.00004936771,0.000008414957,0.0159829,0.0001309662,0.001491807,0.0002040809,0.0007252626,0.00004643741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541206,0.0001195047,0.000005747941,0.02785338,0.000009507884,0.00168641,0.00001776814,0.000004707923,0.01618241],"genre_scores_gemma":[0.9982703,0.0000477348,0.00004466352,0.001159922,0.000004666422,0.000124476,0.00001074303,0.000005948005,0.0003315362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0492738,"threshold_uncertainty_score":0.1625613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07528780780480221,"score_gpt":0.3852517459876553,"score_spread":0.3099639381828531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}