{"id":"W2996589204","doi":"10.1042/bcj20190596","title":"A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells","year":2019,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"TFEB; Autophagy; Biology; Cancer research; Lysosome; Cell biology; Programmed cell death; DNA damage; Apoptosis; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252422,0.0001160969,0.0002437815,0.000119974,0.00002941075,0.00002011084,0.00005088131,0.0001158459,0.00009819388],"category_scores_gemma":[0.00002778097,0.00009874226,0.00009606047,0.0001223678,0.00002154037,0.00008433722,0.00003389748,0.0003375053,0.000002439489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626427,"about_ca_system_score_gemma":0.0001101699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003569651,"about_ca_topic_score_gemma":0.000001443639,"domain_scores_codex":[0.9990212,0.00002185275,0.0003054091,0.0002014441,0.0001793248,0.0002707608],"domain_scores_gemma":[0.9995511,0.00006143037,0.0001064918,0.00008207911,0.00004369948,0.0001552288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004345749,0.0001277543,0.0734842,0.00006925911,0.00003526748,0.00001133716,0.0002116375,0.000003001651,0.9227279,0.000007424583,0.0001183083,0.00276935],"study_design_scores_gemma":[0.00424083,0.00006958941,0.06368931,0.0007983547,0.00002123373,0.0001453906,0.0005247176,0.0005889382,0.9294713,0.0002464333,0.00005555743,0.0001483829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981324,0.0007982832,0.000005448604,0.0006312476,0.00006767634,0.0002533366,0.00001154734,0.00001607419,0.00008397333],"genre_scores_gemma":[0.998765,0.0001504385,0.0002940975,0.0004299719,0.0002862339,0.0000204783,0.000003026086,0.00001840371,0.00003233962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009794896,"threshold_uncertainty_score":0.4026593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007643768811457551,"score_gpt":0.2640127471541178,"score_spread":0.2563689783426603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}