{"id":"W2996589204","doi":"10.1042/bcj20190596","title":"A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells","year":2019,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"TFEB; Autophagy; Biology; Cancer research; Lysosome; Cell biology; Programmed cell death; DNA damage; Apoptosis; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186212,0.0002029585,0.0002215127,0.0001667245,0.0001309645,0.0003010816,0.0001067601,0.0002924479,0.001492466],"category_scores_gemma":[0.0001341695,0.00006200241,0.0002333567,0.0001361936,0.0001282863,0.0002170104,0.0001409915,0.0003582873,0.0005037529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617597,"about_ca_system_score_gemma":0.000149311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003437015,"about_ca_topic_score_gemma":0.0004498379,"domain_scores_codex":[0.9999164,0.00001036572,0.00000647137,0.00002360593,0.0000228045,0.00002034831],"domain_scores_gemma":[0.9999316,0.000009483936,0.00001663789,0.000009729149,0.00001857125,0.00001388325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008461656,0.00001395303,0.0001813756,0.00007180301,0.000005413061,0.00006067787,0.00001197236,0.00003756227,0.9969984,0.00009184446,0.00006861128,0.002373747],"study_design_scores_gemma":[0.00001780588,0.0001273918,0.004924157,0.00001393189,0.0000143009,0.0005706489,0.0000292892,0.0004876694,0.9880856,0.0000676182,0.005657207,0.000004394077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578815,0.02279892,0.01188852,0.0004267156,0.0001100105,0.00005428483,0.001393554,0.000341698,0.005104963],"genre_scores_gemma":[0.9902499,0.002162734,0.001946241,0.0001201891,0.00001282031,0.00003231999,0.0007832105,0.00002102372,0.004671454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492466,"threshold_uncertainty_score":0.004992783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007643768811457551,"score_gpt":0.2640127471541178,"score_spread":0.2563689783426603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}