{"id":"W2996612587","doi":"10.1021/acsmedchemlett.9b00471","title":"Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Myeloid leukemia; Bioavailability; Pharmacology; Leukemia; Benzamide; Histone deacetylase inhibitor; Cytotoxicity; Cancer research; Chemistry; Medicine; Histone deacetylase; Immunology; Biochemistry; In vitro; Gene; Histone; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000511901,0.0003678566,0.0003940154,0.00007124434,0.00007677805,0.00003047285,0.0003311453,0.0003388983,0.00006748011],"category_scores_gemma":[0.0001500631,0.0003524543,0.00009395726,0.0002959817,0.000494746,0.0000113942,0.0002012997,0.0006624013,0.00004914059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603789,"about_ca_system_score_gemma":0.0002886965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008945308,"about_ca_topic_score_gemma":0.00002191983,"domain_scores_codex":[0.9974046,0.0001257528,0.0004002812,0.0009319667,0.0004821163,0.0006553361],"domain_scores_gemma":[0.9988702,0.00008036631,0.0001107859,0.0006077432,0.00009740507,0.0002335037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004061861,0.0000833457,0.004998495,0.000127553,0.00008878354,0.00004488314,0.0001802269,0.00001240105,0.99019,0.000001222233,0.002602123,0.001264778],"study_design_scores_gemma":[0.002553589,0.00019001,0.005837956,0.00008318916,0.00003329277,0.00009810366,0.0001289652,0.00004015633,0.9864659,0.000005781454,0.004175255,0.0003878156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964193,0.0006381086,0.00001115986,0.001567255,0.0001402579,0.0004398368,0.0000167502,0.00002672691,0.0007406021],"genre_scores_gemma":[0.9975639,0.00008487813,0.00006026424,0.00118051,0.000343668,0.00003830414,0.000114779,0.0000485636,0.0005651198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003724116,"threshold_uncertainty_score":0.9998928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008421389672362074,"score_gpt":0.2612491898393479,"score_spread":0.2528278001669859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}