{"id":"W2996612587","doi":"10.1021/acsmedchemlett.9b00471","title":"Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Myeloid leukemia; Bioavailability; Pharmacology; Leukemia; Benzamide; Histone deacetylase inhibitor; Cytotoxicity; Cancer research; Chemistry; Medicine; Histone deacetylase; Immunology; Biochemistry; In vitro; Gene; Histone; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304731,0.0002300755,0.0002835674,0.0001695232,0.0001063087,0.0001744066,0.0001587548,0.0001274163,0.001069128],"category_scores_gemma":[0.0001119688,0.0000918709,0.000143525,0.0001463813,0.0001137821,0.0001012042,0.00008171475,0.0003476386,0.0002592156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240102,"about_ca_system_score_gemma":0.0001732814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033013,"about_ca_topic_score_gemma":0.001740052,"domain_scores_codex":[0.9999464,0.00001027434,0.000004502924,0.000009925312,0.00001134341,0.00001756815],"domain_scores_gemma":[0.9999653,0.000006118884,0.000008744333,0.000004426563,0.00000472512,0.00001062382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001075745,0.000342313,0.0004742008,0.00008373855,0.00001916936,0.00007536502,0.0000188006,0.0004023097,0.9781333,0.0001437076,0.0003471363,0.01888431],"study_design_scores_gemma":[0.0005632848,0.01444391,0.01414988,0.00001641267,0.0001070693,0.0006376139,0.00002614075,0.002195995,0.9600248,0.00008344005,0.007733664,0.00001775806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913674,0.003859506,0.001246116,0.0001155571,0.00001993334,0.00006637944,0.0004351616,0.00009697931,0.002792911],"genre_scores_gemma":[0.9945059,0.002069257,0.0009971635,0.00006348989,0.00001549289,0.00002459523,0.0007103621,0.00001221024,0.001601404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069128,"threshold_uncertainty_score":0.003576577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008421389672362074,"score_gpt":0.2612491898393479,"score_spread":0.2528278001669859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}