{"id":"W2996679182","doi":"10.1016/j.nicl.2019.102121","title":"MRI and cognitive scores complement each other to accurately predict Alzheimer's dementia 2 to 7 years before clinical onset","year":2019,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Gériatrie de Montréal; Université de Montréal; McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; GE Healthcare; Natural Sciences and Engineering Research Council of Canada; Pfizer; Biogen; BioClinica; Roche; University of Southern California; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Psychology; Cognition; Medicine; Neuroscience; Complement (music); Clinical psychology; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006052041,0.00141779,0.0009356412,0.002191477,0.0004189572,0.001603045,0.0005797529,0.001129375,0.001599401],"category_scores_gemma":[0.01190181,0.0003178347,0.000812837,0.0005993019,0.0003581831,0.001295682,0.0007042184,0.0009626757,0.00076954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003023997,"about_ca_system_score_gemma":0.0005329268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002586157,"about_ca_topic_score_gemma":0.006765594,"domain_scores_codex":[0.998682,0.0005267581,0.000163451,0.0002379639,0.0002704231,0.00011947],"domain_scores_gemma":[0.9943592,0.002525389,0.001270598,0.0004553808,0.0008777066,0.0005117201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009978778,0.0004565884,0.9563024,0.00009258153,0.000478953,0.00008011202,0.00008176536,0.002109275,0.0009320658,0.00008683994,0.0009931494,0.03738835],"study_design_scores_gemma":[0.00007397581,0.00173207,0.9647687,0.0001147548,0.0005360305,0.0005691361,0.0001039425,0.02851463,0.001243669,0.001216193,0.001073363,0.00005339953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884885,0.001814233,0.004162082,0.0003727724,0.0001344182,0.0001097459,0.0009343904,0.0001262029,0.003857657],"genre_scores_gemma":[0.9946273,0.0003015571,0.003482652,0.00009315115,0.00007004699,0.00002720311,0.0008517035,0.000008742353,0.0005376467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006052041,"threshold_uncertainty_score":0.03200668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308080926700013,"score_gpt":0.4640269276127675,"score_spread":0.3332188349427663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}