{"id":"W2996679182","doi":"10.1016/j.nicl.2019.102121","title":"MRI and cognitive scores complement each other to accurately predict Alzheimer's dementia 2 to 7 years before clinical onset","year":2019,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Gériatrie de Montréal; Université de Montréal; McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; GE Healthcare; Natural Sciences and Engineering Research Council of Canada; Pfizer; Biogen; BioClinica; Roche; University of Southern California; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Psychology; Cognition; Medicine; Neuroscience; Complement (music); Clinical psychology; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002159298,0.0003113374,0.0007491912,0.000194478,0.00009012225,0.0001136623,0.0002633646,0.0001545756,0.001958358],"category_scores_gemma":[0.001441346,0.000275633,0.0002797628,0.0002901045,0.0002988366,0.0001289346,0.0006306541,0.0007578155,0.002429645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001321639,"about_ca_system_score_gemma":0.0002021565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003270306,"about_ca_topic_score_gemma":0.00003700724,"domain_scores_codex":[0.9954633,0.0005981704,0.00121236,0.001194165,0.0008116709,0.0007203522],"domain_scores_gemma":[0.9967951,0.001120863,0.0001428449,0.0005337897,0.0003250202,0.001082429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001814207,0.0009095885,0.9266122,0.00002599875,0.0009037526,0.0001769191,0.0001007293,2.153343e-7,0.0001188031,0.00001488158,0.01426614,0.05505656],"study_design_scores_gemma":[0.005350462,0.009963096,0.9541721,0.0002016953,0.0008107173,0.00003012851,0.0001412467,0.00007104458,0.000203438,0.00003094388,0.02879207,0.0002330695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990047,0.0001319581,0.0003692531,0.003077958,0.000536627,0.003180046,0.0001884358,0.00008953948,0.002379122],"genre_scores_gemma":[0.9813854,0.00005924439,0.00114337,0.01621195,0.0004167571,0.00009065198,0.00008132788,0.00006863166,0.0005427367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05482349,"threshold_uncertainty_score":0.9999696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308080926700013,"score_gpt":0.4640269276127675,"score_spread":0.3332188349427663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}