{"id":"W2996752769","doi":"10.1016/j.tranon.2019.10.009","title":"Does Bone-targeted Therapy Benefit Patients with Metastatic Renal Cell Carcinoma?","year":2019,"lang":"en","type":"article","venue":"Translational Oncology","topic":"Bone health and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Denosumab; Zoledronic acid; Internal medicine; Hazard ratio; Oncology; Renal cell carcinoma; Osteonecrosis of the jaw; Cohort; Proportional hazards model; Retrospective cohort study; Bone metastasis; Confidence interval; Cancer; Bisphosphonate; Surgery; Metastasis; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006956101,0.0001521692,0.000352074,0.00009058589,0.00005198968,0.000003475673,0.00003616892,0.00008024395,0.001057207],"category_scores_gemma":[0.000001995425,0.00008124252,0.00006525432,0.0001135772,0.00003934087,0.00006883082,0.000002968231,0.0001429194,0.000160232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007226017,"about_ca_system_score_gemma":0.0003536034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009011208,"about_ca_topic_score_gemma":0.000101404,"domain_scores_codex":[0.9989069,0.00004099398,0.0002623695,0.000247717,0.0002800752,0.0002619866],"domain_scores_gemma":[0.9993517,0.0001188451,0.00009295622,0.0001504798,0.0001243138,0.0001617345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003677611,0.001202476,0.9834236,0.00005440607,0.0001061953,0.00003579949,0.0003398567,0.0000349421,0.0003205529,0.0002339422,0.00007069454,0.01049993],"study_design_scores_gemma":[0.01899949,0.003003626,0.9657772,0.00001097903,0.0001001092,0.000007612635,0.00001138855,0.00005638402,0.0004658276,0.0003384753,0.01112171,0.0001072626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992554,0.0003089865,0.00003127899,0.0020546,0.0001611169,0.0009293388,0.00006022051,0.00002847545,0.003871965],"genre_scores_gemma":[0.9935251,0.00001269381,0.003467452,0.001060613,0.00002796325,0.00004111879,0.0005005065,0.0000224113,0.001342093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01764646,"threshold_uncertainty_score":0.9998559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632977037648028,"score_gpt":0.2814199564627172,"score_spread":0.2650901860862369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}