{"id":"W2996764486","doi":"10.1371/journal.ppat.1008231","title":"Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Biomedical Research Council; Mechanobiology Institute, Singapore; National Institutes of Health; National University of Singapore; National Supercomputing Centre Singapore; Texas Biomedical Research Institute; Cancer Prevention and Research Institute of Texas; University of Pennsylvania; Foundation for the National Institutes of Health","keywords":"Cell biology; VP40; WW domain; Filoviridae; NEDD4; Biology; Hippo signaling pathway; Cytoplasm; Ectopic expression; Marburg virus; Ubiquitin ligase; Effector; Chemistry; Ubiquitin; Virology; Viral replication; Virus; Cell culture; Genetics; Gene; Ebola virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097697,0.0002515794,0.0001605126,0.0001620098,0.0001299318,0.0003049492,0.000148625,0.0002108326,0.000379792],"category_scores_gemma":[0.00009662315,0.00009117184,0.000213101,0.00008832086,0.0001796958,0.0002527972,0.0002307528,0.0002457132,0.0001002344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363613,"about_ca_system_score_gemma":0.000102262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002397056,"about_ca_topic_score_gemma":0.0003681472,"domain_scores_codex":[0.9999284,0.00001278854,0.000004935896,0.00001178706,0.00002109101,0.00002102325],"domain_scores_gemma":[0.9999508,0.00000830032,0.00001712263,0.00000368602,0.000004128017,0.00001591203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003677607,0.000005855192,0.0004246188,0.00001383793,0.00000240043,0.00005639119,0.00000664743,0.00008462276,0.9988542,0.0001139038,0.00000646851,0.0003943043],"study_design_scores_gemma":[0.00001422804,0.0003187853,0.01830417,0.000006312371,0.00001358815,0.0007433179,0.00007153437,0.0022331,0.9759388,0.00024249,0.002105047,0.000008597786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971216,0.001203226,0.001081797,0.00004967181,0.000004988499,0.000008292083,0.00007044084,0.00001197265,0.0004478716],"genre_scores_gemma":[0.9978701,0.0007218347,0.0008925339,0.00001843464,0.000004810352,0.000008608064,0.000138082,0.000003720929,0.0003419349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000379792,"threshold_uncertainty_score":0.001714945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238486956281111,"score_gpt":0.2545679845487729,"score_spread":0.2221831149859618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}