{"id":"W2996764486","doi":"10.1371/journal.ppat.1008231","title":"Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Biomedical Research Council; Mechanobiology Institute, Singapore; National Institutes of Health; National University of Singapore; National Supercomputing Centre Singapore; Texas Biomedical Research Institute; Cancer Prevention and Research Institute of Texas; University of Pennsylvania; Foundation for the National Institutes of Health","keywords":"Cell biology; VP40; WW domain; Filoviridae; NEDD4; Biology; Hippo signaling pathway; Cytoplasm; Ectopic expression; Marburg virus; Ubiquitin ligase; Effector; Chemistry; Ubiquitin; Virology; Viral replication; Virus; Cell culture; Genetics; Gene; Ebola virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465709,0.0001430191,0.0001681993,0.00001694693,0.0001577132,0.00001166198,0.0001472498,0.0001241153,0.000005850213],"category_scores_gemma":[0.0001690689,0.0001155883,0.00007608061,0.00006119351,0.0001089733,0.000002370122,0.0001520713,0.00007981181,8.793397e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005062502,"about_ca_system_score_gemma":0.00003639055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005949955,"about_ca_topic_score_gemma":0.000002160678,"domain_scores_codex":[0.9990964,0.00009361458,0.0002015966,0.0003663246,0.0000463654,0.0001957164],"domain_scores_gemma":[0.9994554,0.00004294224,0.00009700653,0.0002511384,0.00005681023,0.00009671606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002437341,0.00004051223,0.0025823,0.00004354306,0.00006071498,2.259112e-7,0.000162161,0.000008035834,0.9943202,0.000163216,0.0001754443,0.002419232],"study_design_scores_gemma":[0.0003677538,0.0002484464,0.0008893764,0.00001155541,0.00005668002,0.000002658694,0.00007451995,0.000212743,0.9804598,0.0002533427,0.01726546,0.0001576592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993217,0.001787368,0.001958004,0.0008222785,0.00003542476,0.0003586422,0.001738778,0.00001289812,0.00006963294],"genre_scores_gemma":[0.9975385,0.0003036886,0.001066576,0.0007030684,0.0001006431,0.00007375448,0.0001534263,0.00002330122,0.00003701911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01709002,"threshold_uncertainty_score":0.4713553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238486956281111,"score_gpt":0.2545679845487729,"score_spread":0.2221831149859618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}