{"id":"W2996789825","doi":"10.1016/j.preteyeres.2019.100827","title":"Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives","year":2019,"lang":"en","type":"review","venue":"Progress in Retinal and Eye Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"Blinding; Clinical trial; Genetic enhancement; Medicine; Retinal Disorder; Genetic counseling; Intensive care medicine; Bioinformatics; Retinal; Ophthalmology; Pathology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.008077288,0.0006145371,0.002140277,0.0004750003,0.0001947995,0.0002722681,0.0004442731,0.0007881539,0.00001199577],"category_scores_gemma":[0.0009467908,0.0004547687,0.0003715908,0.0005554346,0.0009804146,0.0000240917,0.0003912742,0.0009503235,0.000003161287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000431741,"about_ca_system_score_gemma":0.0006775477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001572605,"about_ca_topic_score_gemma":0.00001858823,"domain_scores_codex":[0.9920733,0.003499822,0.001617831,0.001342305,0.0005051658,0.0009615682],"domain_scores_gemma":[0.997723,0.0008625719,0.0005182244,0.0003571473,0.0002755179,0.0002635147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001734452,0.0001697314,0.400986,0.00416428,0.0001074816,0.00002755032,0.0001218589,1.00817e-8,0.000002071486,0.0000336492,0.0000582118,0.5925947],"study_design_scores_gemma":[0.008301135,0.006020946,0.2893283,0.01514184,0.0003045682,0.00006406195,0.0009735164,0.0000493239,0.00004933538,0.0002949235,0.6775067,0.001965279],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1611918,0.835313,0.000002979945,0.0001625145,0.0001057353,0.003014238,0.0001203249,0.00001121993,0.00007815558],"genre_scores_gemma":[0.01235706,0.9833431,0.0007807837,0.00001434404,0.0007392865,0.001668403,0.0008953214,0.00008356885,0.0001181514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6774485,"threshold_uncertainty_score":0.9997904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2069908399127471,"score_gpt":0.5289925738643262,"score_spread":0.322001733951579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}