{"id":"W2996918050","doi":"10.1053/j.gastro.2019.12.020","title":"Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; European Regional Development Fund; Instituto de Salud Carlos III; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; U.S. Public Health Service; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Bundesministerium für Bildung und Frauen; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Ontario Institute for Cancer Research; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Institut National de la Santé et de la Recherche Médicale; Conseil Régional des Pays de la Loire; European Cooperation in Science and Technology; Ministerstvo Zdravotnictví Ceské Republiky; Centre Hospitalier Universitaire de Nantes; European Commission; Generalitat de Catalunya; Food Standards Agency; Chonnam National University; Centres de Recerca de Catalunya; Institut Gustave-Roussy; Grantová Agentura České Republiky; U.S. Department of Health and Human Services; Mayo Clinic; Johns Hopkins University; Centre International de Recherche sur le Cancer; Cancer Research Foundation in Northern Sweden; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; University of Pittsburgh; Stockholms Läns Landsting; Cancer Council Victoria; Kræftens Bekæmpelse; Memorial Sloan-Kettering Cancer Center; National Research Council; Association Anne de Bretagne Genetique; Swedish Cancer Foundation; University of South Florida; Österreichische Forschungsförderungsgesellschaft; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Heart, Lung, and Blood Institute; Florida Department of Health; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; University of Cambridge; American Cancer Society; VicHealth; Mutuelle Générale de l'Education Nationale; Ministerie van Volksgezondheid, Welzijn en Sport; American Institute for Cancer Research; Damon Runyon Cancer Research Foundation; Moffitt Cancer Center; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute","keywords":"Mendelian randomization; IGFBP3; Colorectal cancer; Medicine; Hazard ratio; Oncology; Internal medicine; Odds ratio; Cancer; Insulin-like growth factor; Risk factor; Proportional hazards model; Confidence interval; Genotype; Biology; Growth factor; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004270232,0.0005139704,0.001457477,0.0006517685,0.0001132779,0.00002167587,0.0001491125,0.0003259521,0.00008800024],"category_scores_gemma":[0.0003651947,0.0003926448,0.0001712787,0.0004262395,0.0002729399,0.0002063261,0.00009032973,0.0005222058,0.000002872392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375153,"about_ca_system_score_gemma":0.0001288206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004417507,"about_ca_topic_score_gemma":0.00009984063,"domain_scores_codex":[0.9966906,0.0005270469,0.0009170825,0.0007272026,0.0004956346,0.0006424487],"domain_scores_gemma":[0.9976241,0.0003025716,0.001131721,0.0002674898,0.0004327636,0.0002413258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008849352,0.0002135837,0.855153,0.0002948294,0.0005897233,0.0000135944,0.0004320292,0.0001225642,0.1340214,0.000007642036,0.000006769172,0.0002954885],"study_design_scores_gemma":[0.02367948,0.006847074,0.9325916,0.0002733926,0.0004467987,0.00002642462,0.000158542,0.004391053,0.03130265,0.00002806308,0.000002842681,0.0002521355],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967274,0.0001441188,0.0006221019,0.0002036004,0.0001674014,0.001479691,0.000550892,0.00006041687,0.00004438261],"genre_scores_gemma":[0.9982848,0.0001561192,0.000995604,0.0003069513,0.00003951024,0.00006573653,0.00007242491,0.00006109803,0.00001771451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1027188,"threshold_uncertainty_score":0.9998525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424444684685509,"score_gpt":0.2669388121055197,"score_spread":0.2426943652586646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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