{"id":"W2996918050","doi":"10.1053/j.gastro.2019.12.020","title":"Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; European Regional Development Fund; Instituto de Salud Carlos III; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; U.S. Public Health Service; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Bundesministerium für Bildung und Frauen; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Ontario Institute for Cancer Research; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Institut National de la Santé et de la Recherche Médicale; Conseil Régional des Pays de la Loire; European Cooperation in Science and Technology; Ministerstvo Zdravotnictví Ceské Republiky; Centre Hospitalier Universitaire de Nantes; European Commission; Generalitat de Catalunya; Food Standards Agency; Chonnam National University; Centres de Recerca de Catalunya; Institut Gustave-Roussy; Grantová Agentura České Republiky; U.S. Department of Health and Human Services; Mayo Clinic; Johns Hopkins University; Centre International de Recherche sur le Cancer; Cancer Research Foundation in Northern Sweden; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; University of Pittsburgh; Stockholms Läns Landsting; Cancer Council Victoria; Kræftens Bekæmpelse; Memorial Sloan-Kettering Cancer Center; National Research Council; Association Anne de Bretagne Genetique; Swedish Cancer Foundation; University of South Florida; Österreichische Forschungsförderungsgesellschaft; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Heart, Lung, and Blood Institute; Florida Department of Health; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; University of Cambridge; American Cancer Society; VicHealth; Mutuelle Générale de l'Education Nationale; Ministerie van Volksgezondheid, Welzijn en Sport; American Institute for Cancer Research; Damon Runyon Cancer Research Foundation; Moffitt Cancer Center; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute","keywords":"Mendelian randomization; IGFBP3; Colorectal cancer; Medicine; Hazard ratio; Oncology; Internal medicine; Odds ratio; Cancer; Insulin-like growth factor; Risk factor; Proportional hazards model; Confidence interval; Genotype; Biology; Growth factor; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003185627,0.0004565317,0.0003721483,0.000910279,0.0002357226,0.0004633216,0.0003374707,0.0003774682,0.002447712],"category_scores_gemma":[0.01037134,0.0002369143,0.0007034453,0.000743271,0.0004921661,0.0001982917,0.0002855168,0.0003205219,0.000149361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032207,"about_ca_system_score_gemma":0.0001879526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408931,"about_ca_topic_score_gemma":0.0009857138,"domain_scores_codex":[0.9966844,0.001974916,0.0002136909,0.0007309794,0.0002737934,0.0001221797],"domain_scores_gemma":[0.9932283,0.003351141,0.002115989,0.0009125963,0.0001835208,0.000208599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006085795,0.00008331665,0.9734492,0.00006481489,0.00150012,0.0004328043,0.0001352639,0.000468015,0.01064802,0.0004544124,0.0003284081,0.006349823],"study_design_scores_gemma":[0.000340745,0.0009050121,0.9876467,0.00001816507,0.0007673727,0.00270142,0.00006578442,0.004114686,0.002293222,0.0006159248,0.0005110044,0.00001998177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961522,0.000374601,0.002712674,0.00007462143,0.00001634399,0.0000205719,0.0002711204,0.00003310172,0.0003445702],"genre_scores_gemma":[0.9984102,0.00003935763,0.001274272,0.00002219238,0.000007387966,0.00001456762,0.000123357,0.000006792555,0.0001017388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003185627,"threshold_uncertainty_score":0.01684743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424444684685509,"score_gpt":0.2669388121055197,"score_spread":0.2426943652586646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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