{"id":"W2996922641","doi":"10.3762/bjoc.16.1","title":"Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction","year":2020,"lang":"en","type":"article","venue":"Beilstein Journal of Organic Chemistry","topic":"Catalytic Alkyne Reactions","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Cancer Institute; Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Nucleophile; Alkene; Propargyl; Nucleoside; Pyrimidine; Stereochemistry; Ether; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109411,0.0003859193,0.0001561535,0.0001326373,0.0001221124,0.0002145156,0.0002967414,0.0002429621,0.001137396],"category_scores_gemma":[0.0001306514,0.0001561259,0.0001511543,0.0001174154,0.000183262,0.0002449637,0.0002813927,0.0003570416,0.0003871149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420389,"about_ca_system_score_gemma":0.0001925889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005344743,"about_ca_topic_score_gemma":0.001419615,"domain_scores_codex":[0.9999285,0.000009095785,0.000006560213,0.00002138987,0.00001570831,0.00001871585],"domain_scores_gemma":[0.999948,0.000006705906,0.00001605448,0.000009954231,0.000007351005,0.00001188308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006680426,0.00001426398,0.0000811226,0.00007528976,0.000007279828,0.0001449485,0.00004361819,0.0002219636,0.9949005,0.001038643,0.00004664836,0.003359009],"study_design_scores_gemma":[0.000007622257,0.0001348501,0.0002469921,0.000003307042,0.000007817544,0.0001492916,0.00000815474,0.0003006878,0.9960872,0.00005514493,0.002993701,0.000005281107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777229,0.001433914,0.0107874,0.00006236027,0.00006332254,0.00007241848,0.0001616349,0.0001517799,0.009544319],"genre_scores_gemma":[0.9889191,0.0008478952,0.006846935,0.00001936064,0.000007875019,0.00002288489,0.0001241235,0.00002492636,0.003186903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137396,"threshold_uncertainty_score":0.003804982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02575553166904345,"score_gpt":0.2348076922611501,"score_spread":0.2090521605921067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}