{"id":"W2997063991","doi":"10.1007/s11095-019-2724-2","title":"Novel Approach for the Bioequivalence Assessment of Topical Cream Formulations: Model-Based Analysis of Tape Stripping Data Correctly Concludes BE and BIE","year":2020,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université de Montréal","funders":"","keywords":"Bioequivalence; Stratum corneum; Pharmacokinetics; Mathematics; Chromatography; Medicine; Stripping (fiber); Pharmacology; Chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002296623,0.0001879683,0.0004561053,0.0002163538,0.0003459373,0.00002313908,0.001088884,0.0001677813,0.000226319],"category_scores_gemma":[0.001019569,0.0001492545,0.0001313228,0.001128783,0.001324704,0.000183326,0.0005653501,0.001041578,5.046928e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006356565,"about_ca_system_score_gemma":0.0003263451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002048855,"about_ca_topic_score_gemma":0.000004846115,"domain_scores_codex":[0.9970945,0.0004428219,0.000611128,0.0005788399,0.0007183141,0.0005544255],"domain_scores_gemma":[0.9919512,0.00669837,0.0001259952,0.000457202,0.0004433662,0.0003238801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002635462,0.002622251,0.02127188,0.001574692,0.004209687,0.000004351695,0.001004789,0.6601307,0.2394869,0.01951595,0.0006549085,0.04688841],"study_design_scores_gemma":[0.001890918,0.0001970659,0.0009501958,0.0000112961,0.001507734,5.998562e-7,0.000262106,0.9706215,0.02006112,0.00006782609,0.004293857,0.0001357404],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03190871,0.001050055,0.9597279,0.003321663,0.00007515063,0.001402349,0.001766838,0.00002568768,0.0007216753],"genre_scores_gemma":[0.9716575,0.0007456118,0.02583883,0.001283238,0.00006718854,0.0001272799,0.0002357568,0.00001837371,0.00002628223],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9397488,"threshold_uncertainty_score":0.6086422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7521730440483944,"score_gpt":0.6327760426779995,"score_spread":0.1193970013703949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}